Baseline clinical and biological characteristics of patients with worsening MC vasculitis after RTX.
| Patient | Sex | Age, yrs | Etiology | HCV Cured | Symptoms | Cryo before/after RTX, g/l | Creatinemia before/after RTX, ยตmol/l | Gammaglobulin Level before RTX, g/l | C4 before/after RTX, g/l | Albumin, g/l |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | M | 49 | HCV, lymphoproliferation | Yes | Fever, renal, cutaneous, GI tract | 0.09/0.52 | 117/455 | 5.2 | < 0.06/< 0.01 | 30.4 |
| 2 | F | 78 | HCV, SLE, MZL | No | Renal, CNS | 1.62/ND | 76/200 | 4.7 | 0.02/ND | 27 |
| Yes | Renal, cutaneous, neuropathy | 0.38/0.57 | 69/200 | 2.3 | 0.01/0.01 | 43 | ||||
| 3 | M | 78 | HCV, MZL | No | Renal, cutaneous, neuropathy | 2.2/0.5 | 125/450 | 2.9 | ND/< 0.01 | 35 |
| 4 | M | 34 | HCV | Yes | Renal, cutaneous, neuropathy | ND/1.5 | 138/250 | ND | ND/0.06 | ND |
| 5 | M | 59 | HCV | 0 | Renal, cutaneous, neuropathy, GI tract | 2.56/ND | 58/ND | 13.8 | 0.02/ND | 39 |
| 6 | F | 75 | HCV, lympho-proliferation | 0 | Renal, cutaneous, neuropathy, GI tract | 0.9/1.18 | 375/430 | 2.9 | 0.01/0.02 | 32 |
| 7 | M | 83 | Essential | NA | Cutaneous, neuropathy | 1.2/ND | 66/172 | 2.3 | < 0.05/ND | ND |
Note: Patient 2 had 2 disease flares. MC: mixed cryoglobulinemia; RTX: rituximab; HCV: hepatitis C virus; SLE: systemic lupus erythematosus; MZL: marginal zone lymphoma; CNS: central nervous system; GI: gastrointestinal; Cryo: cryoglobulin; ND: not determined, NA: not applicable.