Association between vascular pathology and hand osteoarthritis (OA).
| Author, Year | Exposure and Exposure Measurement | Confounder Adjusted for | Results | Conclusion |
|---|---|---|---|---|
| Cohort studies | ||||
| Hoeven, et al6, 2013 | Common carotid artery: atherosclerosis by IMT and atheromatous plaques | Age, BMI, total cholesterol/HDL ratio, diabetes, hypertension, and smoking | Cross-sectional analysis: Women, carotid plaque DIP: OR 1.4, 95% CI 1.19–1.65 PIP: OR 1.1, 95% CI, 0.90–1.40 MCP: OR 1.5, 95% CI 1.09–2.18 CMC/TS: OR 1.0, 95% CI 0.88–1.24 Women, carotid IMT DIP: OR 1.4, 95% CI 0.93–2.10 PIP: OR 1.3, 95% CI 0.81–2.22 MCP: OR 1.6, 95% CI 0.84–2.94 CMC/TS: OR 1.0, 95% CI 0.68–1.59 Men, carotid plaque DIP: OR 1.0, 95% CI 0.76–1.18 PIP: OR 0.9, 95% CI 0.66–1.24 MCP: OR 1.3, 95% CI 0.78–1.80 CMC/TS: OR 1.0, 95% CI 0.78–1.28 Men, carotid IMT DIP: OR 1.1, 95% CI 0.67–1.64 PIP: OR 0.8, 95% CI 0.40–1.40 MCP: OR 1.0, 95% CI 0.46–2.06 CMC/TS: OR 0.9, 95% CI 0.56–1.54 Longitudinal analysis: progression Women, carotid plaque DIP: OR 1.1, 95% CI 0.86–1.34 PIP: OR 1.0, 95% CI 0.77–1.29 MCP: OR 0.9, 95% CI 0.67–1.22 CMC/TS: OR 0.9, 95% CI 0.68–1.13 Women, carotid IMT DIP: OR 1.3, 95% CI 0.65–2.66 PIP: OR 0.6, 95% CI 0.26–1.34 MCP: OR 2.9, 95% CI 1.18–6.93 CMC/TS: OR 0.6, 95% CI 0.25–1.27 Men No significant association was shown either with carotid plaque or carotid IMT Data were not presented | Carotid plaque was associated with DIP and MCP, but not PIP or CMC/TS OA in women but not men. IMT but not plaque was associated with progression of MCP OA in women only. |
| Case-control studies | ||||
| Koutroumpas, et al9, 2013 | IMT and atheromatous plaques in the common carotid and common femoral arteries The endothelium-dependent, flow-mediated dilatation (FMD) and endothelium-independent, NMD of the brachial artery | Age and sex | Erosive hand OA IMT > 1 mm (OR 3.33, 95% CI 1.02–10.9) Plaque (OR 1.41, 95% CI 0.46–4.46) Difference between FMD and NMD increased in erosive OA (p = 0.026) | Subclinical atherosclerosis was associated with erosive hand OA. |
| Cross-sectional studies | ||||
| Jonsson,et al28, 2019 | Generalized vascular pathology Retinal vascular caliber (arteriolar and venular) | Age, sex, BMI | Total population Arteriolar caliber: OR 1.08, 95% CI 1.02–1.15 Venular caliber: OR 1.08, 95% CI 1.02–1.14 Women Arteriolar caliber: OR 1.08, 95% CI 1.00–1.17 Venular caliber: OR 1.09, 95% CI 1.01–1.18 Men Arteriolar caliber: OR 1.22, 95% CI 1.00–1.51 Venular caliber: OR 1.06, 95% CI 0.97–1.16 | There was a positive association between narrow arteriolar caliber and hand OA in both men and women. Further, there was a positive association for narrower venular caliber and hand OA only for women. |
| Cemeroglu, et al31, 2014 | Gensini scoring of coronary angiogram was used to evaluate the patients for atherosclerosis and its severity | Not adjusted for confounders | Gensini score: hand OA vs no hand OA (21.5 ± 17.1 vs 11.8 ± 9.2, respectively; p = 0.017) Correlation between Gensini score and OA score: r = 0.332; p = 0.009 | Atherosclerosis was associated with the presence of hand OA. |
| Jonsson, et al7, 2009 | IMT and plaque severity in common carotid artery Calcium in the coronary arteries CT scan of entire thoracic aorta | Age, smoking, cholesterol, triglycerides, BMI, pulse pressure, and statin use. | Women Carotid plaque: OR 1.25, 95% CI 1.04–1.49; the proportion of women with moderate or severe carotid plaqueincreased with the severity of hand OA, p for trend < 0.0002. Coronary calcification: OR 1.42, 95% CI 1.14–1.76; the proportion of women with no detectable coronary calcification decreased with the severity of hand OA, p for trend = 0.027. Aortic calcification (mm) hand OA/no hand OA: 7.66 (0.04)/7.57 (0.06), p > 0.05 Men Carotid plaque: OR 1.02, 95% CI 0.83–1.25 Coronary calcification: OR 1.13, 95% CI 0.67–1.83 Aortic calcification (mm) hand OA/no hand OA: 7.51 (0.05)/7.4 (0.06), p > 0.05 | There was a linear association between severity of atherosclerosis and the severity of hand OAin women but not men. |
| Saleh, et al11, 2007 | Vascular stiffness by arterial PWV in right common carotid artery and right femoral artery | Age, BMI, sex, systolic and diastolic blood pressure, smoking, and diabetes status | PWV regression coefficient 9.2, 95% CI–64.2, 82.5 | There was no association between PWV and hand OA. |
BMI: body mass index; IMT: intima-media thickness; HDL: high-density lipoprotein; PWV: pulse wave velocity; FMD: flow-mediated dilatation; NMD: sublingual glyceryl trinitrate–induced dilatation; DIP: distal interphalangeal joint; PIP: proximal IP joint; MCP: metacarpophalangeal joint; CMC/TS: carpometacarpal/trapezioscaphoid; CT: computed tomography.