The average effect of multiple comorbidities* on fibromyalgia (FM) and FM-related variables in 12,215 patients.
| No. Comorbidities | Comorbidity Prevalence (%) | PSD Average Comorbidity Effect | WPI Average Comorbidity Effect | SSS Average Comorbidity Effect | FM Average Comorbidity Effect | FM %, Comorbidity (+) vs Comorbidity (–) | WSP, Average Comorbidity Effect vs | WSP %, Comorbidity (+) Comorbidity (–) |
|---|---|---|---|---|---|---|---|---|
| 0 | 51.7 | |||||||
| ≥ 1 | 48.3 | 3.0 (2.7–3.3) | 1.8 (1.6–2.0) | 1.2 (1.1–1.3) | 12.2 (10.6–13.8) | 32.6 vs 20.4 | 13.4 (11.5–15.2) | 59.2 vs 45.6 |
| 1 | 28.9 | 2.0 (1.7–2.3) | 1.2 (1.0–1.5) | 0.8 (0.7–0.9) | 7.5 (5.7–9.3) | 27.9 vs 20.4 | 10.5 (8.5–12.6) | 56.1 vs 45.6 |
| 2 | 12.5 | 4.0 (3.6–4.4) | 2.4 (2.1–2.7) | 1.6 (1.4–1.7) | 16.7 (14.0–19.4) | 37.1 vs 20.4 | 16.3 (13.5–19.2) | 61.9 vs 45.6 |
| 3 | 4.5 | 5.8 (5.1–6.5) | 3.6 (3.0–4.2) | 2.2 (2.0–2.5) | 26.4 (21.7–31.2) | 46.0 vs 20.4 | 25.7 (21.0–30.4) | 71.3 vs 45.6 |
| 4+ | 2.5 | 7.8 (6.5–9.0) | 4.7 (3.7–5.7) | 3.1 (2.7–3.5) | 34.9 (27.2–42.6) | 55.2 vs 20.4 | 26.8 (19.7–34.0) | 72.4 vs 45.6 |
↵* Does not include psychological comorbidity. Data are % (95% CI) unless otherwise indicated. Comorbidities range from 0 to 11. PSD: polysymptomatic distress scale; WPI: widespread pain index; SSS: symptom severity score; WSP: widespread pain.