Table 2.

The average effect of individual comorbidity on fibromyalgia (FM) and FM-related variables in 12,215 patients.

ComorbidityComorbidity Prevalence (%)PSD Average Comorbidity EffectWPI Average Comorbidity EffectSSS Average Comorbidity EffectFM Average Comorbidity EffectFM %, Comorbidity (+) vs Comorbidity (–)
Psychological24.75.0 (4.6–5.3)2.4 (2.2–2.7)2.5 (2.4–2.6)23.3 (21.0–25.6)46.3 vs 20.2
Neurologic2.94.2 (3.3–5.2)2.5 (1.7–3.2)1.8 (1.4–2.1)18.0 (12.1–23.8)43.8 vs 25.8
Stroke0.74.0 (1.5–6.5)3.3 (0.5–4.1)1.7 (0.7–2.6)20.0 (6.9–33.1)46.2 vs 26.2
GI19.33.3 (3.0–3.7)2.0 (1.7–2.2)1.4 (1.2–1.5)14.2 (11.9–16.4)37.4 vs 23.2
GI (w/o IBS)*11.02.8 (2.3–3.2)1.6 (1.2–1.9)1.1 (1.0–1.4)10.4 (7.3–13.4)30.1 vs 19.8
Pulmonary15.32.9 (2.4–3.3)1.8 (1.5–2.1)1.0 (0.9–1.2)11.9 (9.4–14.4)36.3 vs 24.4
Renal3.52.8 (2.0–3.7)1.6 (0.9–2.2)1.3 (0.9–1.6)11.7 (6.0–17.3)37.7 vs 26.0
Fracture2.22.6 (1.4–3.9)1.5 (0.7–2.4)1.1 (0.6–1.5)12.1 (5.4–18.8)38.2 vs 26.1
Heart disease7.82.3 (1.8–2.8)1.3 (0.9–1.7)1.0 (0.8–1.2)10.3 (6.8–13.8)35.7 vs 25.4
Cancer2.32.1 (1.1–3.1)1.2 (0.4–2.0)0.9 (0.5–1.3)13.5 (6.6–20.5)39.6 vs 26.1
Cataract9.51.8 (1.2–2.4)1.0 (0.6–1.5)0.7 (0.5–1.0)7.5 (4.0–10.9)33.2 vs 25.7
GU3.41.8 (0.9–2.7)1.0 (0.3–1.7)0.8 (0.5–1.9)6.0 (0.03–12.0)32.1 vs 26.1
Diabetes12.01.4 (0.9–2.0)0.8 (0.4–1.2)0.6 (0.4–0.8)5.6 (2.1–9.0)31.3 vs 25.7
  • Data are % (95% CI) unless otherwise indicated.

  • * n = 9334. Analyses of each comorbidity are nearest neighbor matched 1:4 (comorbid condition: not comorbid condition) on age sex total household income body mass index smoking status (never past current) and hypertension. PSD: polysymptomatic distress scale; WPI: widespread pain index; SSS: symptom severity scale; GI: gastrointestinal; IBS: irritable bowel syndrome; GU: genitourinary.