Characteristics of patients among Olmsted County, Minnesota, residents with incident gout in 1989–1992 compared with 2009–2010 at the time of incident gout attack.
| Characteristics | 1989–1992, n = 158 | 2009–2010, n = 271 | p |
|---|---|---|---|
| Age at diagnosis, yrs, mean ± SD | 59.3 ± 17.9 | 60.0 ± 17.0 | 0.68 |
| Sex, male | 116 (73) | 196 (72) | 0.81 |
| Race and ethnicity, white | 149W(94) | 244W(90) | 0.17 |
| LengthWofWfollowup, yrs, mean ± SD | 4.1 ± 1.6 | 4.2 ± 1.2 | – |
| Comorbidities at incidence attack | |||
| Body mass index, kg/m2, mean ± SD | 28.6 ± 5.3 | 32.0 ± 6.8 | < 0.001 |
| Kidney disease | 18 (11) | 77 (28) | < 0.001 |
| Hypertension | 86 (54) | 188 (69) | 0.002 |
| Diabetes mellitus | 9 (6) | 68 (25) | < 0.001 |
| Hyperlipidemia | 33 (21) | 164 (61) | < 0.001 |
| Trauma to the affected joint within preceding 4 weeks | 7 (4) | 30 (11) | 0.017 |
| Serum uric acid level prior to incident attack, mean ± SD | 8.1 ± 1.6 | 8.4 ± 2.7 | 0.58 |
| > 1 joint involved at incident attack | 13 (8) | 28 (10) | 0.47 |
| Isolated podagra | 117 (74) | 159 (59) | 0.001 |
| Podagra (with or without other joint involvement) | 126 (80) | 181 (67) | 0.004 |
| Hand, small joints | 6 (4) | 21 (8) | 0.10 |
| Wrist | 3 (2) | 5 (2) | 0.97 |
| Knee | 7 (4) | 17 (6) | 0.42 |
| Foot, small joints (excluding first MTP) | 7 (4) | 35 (13) | 0.004 |
| Ankle | 18 (11) | 33 (12) | 0.81 |
| Mid-foot | 4 (3) | 6 (2) | 0.83 |
| Other (elbow)* | 4 (3) | 1 (0.4) | 0.044 |
| Treatment of incident flare | |||
| Intraarticular GC injection | 1 (1) | 42 (15) | < 0.001 |
| Oral GC | 2 (1) | 59 (22) | < 0.001 |
| Colchicine | 18 (11) | 34 (13) | 0.72 |
| NSAID | 137 (87) | 188 (69) | < 0.001 |
| Starting uric acid–lowering therapy in first 30 days after incident attack | 11 (7) | 49 (18) | 0.001 |
| Ever used uric acid–lowering therapy | 55 (35) | 152 (56) | < 0.001 |
| Allopurinol | 54 (34) | 129 (48) | 0.007 |
| Losartan | 0 (0) | 43 (16) | < 0.001 |
| Fenofibrate | 0 (0) | 13 (5) | 0.005 |
Values are n (%) unless otherwise specified.
↵* Shoulder and hip were not involved in any patients. MTP: metatarsophalangeal; GC: glucocorticoid; NSAID: nonsteroidal antiinflammatory drug.