Comparison of patients with progression (drop in FVC > 10%, and/or drop in DLCO > 15% or death in followup) with patients with no progression or with improvement.
| Variables | Patients with Progression, n = 28 (24%) | Patients without Progression or with Improvement, n = 90 (76%) | cOR (95% CI), p | aOR (95% CI), p |
|---|---|---|---|---|
| Age at baseline evaluation*, mean ± SD | 57.75 ± 10.47 | 52.43 ± 11.60 | 1.04 (1.002–1.08), 0.04 | 1.02 (0.97–1.07), 0.34 |
| Male sex | 8 (28.6) | 25 (28) | 1.04 (0.40–2.66), 0.93 | |
| Extent of lung disease in HRCT according to Goh score, mean ± SD | 48.3 ± 18.19 | 50.2 ± 23.3 | 0.99 (0.97–1.02), 0.70 | |
| Extent of ground glass in HRCT according to Goh score*, mean ± SD† | 37.82 ± 19.66 | 45.51 ± 18.51 | 0.97 (0.95–1.002), 0.08 | 0.98 (0.95–1.01), 0.42 |
| Extent of fibrosis in HRCT according to Goh score† | 7.2 (2.9–19.2) | 5.76 (2.64–8.64) | 1.03 (0.99–1.07), 0.097 | |
| Baseline % of DLCO** | 52.2 ± 26.2 | 52 ± 27.7 | 1.0002 (0.98–1.01), 0.97 | |
| Baseline % of FVC | 60 (43–81.5) | 53.3 (42–74) | 1.009 (0.99–1.02), 0.35 | |
| Patients unable to perform DLCO at baseline due to the severity of lung disease** | 6 (21.5) | 7 (8) | 3.23 (0.98–10.60), 0.053 | 5.95 (1.34–26.41), 0.02 |
| UIP HRCT pattern* | 8 (28.6) | 7 (8) | 4.74 (1.53–14.62), 0.007 | 3.45 (0.85–13.99), 0.082 |
| Anti-Jo1 positivity | 12 (42.8) | 38 (42.2) | 1.02 (0.43–2.41), 0.95 | |
| Ro52-positive | 14/28 (56) | 50/81 (62) | 0.78 (0.31–1.95), 0.60 | |
| Smoking history (current/former) | 9 (32) | 35 (39) | 0.74 (0.30–1.82), 0.52 |
Values are n (%) unless otherwise specified.
↵* Variables with p < 0.15 in the univariate analysis were included in a multivariable logistic regression analysis to adjust for confounding. All possible interactions were evaluated, and none was found.
↵** Data from 105 patients; 13 patients were unable to perform DLCO because of the severity of lung disease.
↵† This variable was not included in the multivariable analysis because of its collinearity with UIP HRCT pattern. FVC: forced vital capacity; cOR: crude OR; aOR: adjusted OR; HRCT: high-resolution computed tomography; UIP: usual interstitial pneumonia.