New CV events in RA with IR and DM versus the reference population.
| All Patients | HR | 95% CI | p |
|---|---|---|---|
| Model 1 | |||
| Reference population, normal glucose tolerance | 1.00 | Reference | — |
| Insulin resistance | 1.46 | 1.04–2.07 | 0.03 |
| DM | 1.51 | 1.03–2.23 | 0.04 |
| RA | |||
| Normal glucose tolerance | 2.08 | 1.58–2.74 | < 0.01 |
| Insulin resistance | 2.70 | 1.33–5.49 | < 0.01 |
| DM | 2.23 | 1.04–4.75 | 0.04 |
| Model 2 | |||
| Reference population, normal glucose tolerance | 1.00 | Reference | — |
| Insulin resistance | 1.18 | 0.82–1.70 | 0.37 |
| DM | 1.30 | 0.87–1.95 | 0.20 |
| RA | |||
| Normal glucose tolerance | 1.89 | 1.37–2.56 | < 0.01 |
| Insulin resistance | 2.67 | 1.30–5.46 | < 0.01 |
| DM | 2.21 | 1.01–4.80 | 0.046 |
Model 1: adjusted for age and sex. Model 2: adjusted for age, sex, systolic blood pressure, antihypertensive agents, total cholesterol, high-density lipoprotein cholesterol, statins, smoking in pack-years, body mass index, aspirin, and prevalent CV disease. CV: cardiovascular; RA: rheumatoid arthritis; IR: insulin resistance; DM: type 2 diabetes mellitus.