Table 4.

New CV events in RA with IR and DM versus the reference population.

All PatientsHR95% CIp
Model 1
  Reference population, normal glucose tolerance1.00Reference
  Insulin resistance1.461.04–2.070.03
  DM1.511.03–2.230.04
  RA
    Normal glucose tolerance2.081.58–2.74< 0.01
    Insulin resistance2.701.33–5.49< 0.01
    DM2.231.04–4.750.04
Model 2
  Reference population, normal glucose tolerance1.00Reference
  Insulin resistance1.180.82–1.700.37
  DM1.300.87–1.950.20
  RA
    Normal glucose tolerance1.891.37–2.56< 0.01
    Insulin resistance2.671.30–5.46< 0.01
    DM2.211.01–4.800.046
  • Model 1: adjusted for age and sex. Model 2: adjusted for age, sex, systolic blood pressure, antihypertensive agents, total cholesterol, high-density lipoprotein cholesterol, statins, smoking in pack-years, body mass index, aspirin, and prevalent CV disease. CV: cardiovascular; RA: rheumatoid arthritis; IR: insulin resistance; DM: type 2 diabetes mellitus.