Table 2.

HR for new CV events in patients with RA versus the reference population.

CharacteristicsRA PopulationReference Populationp
All patients, n3261869
  Total followup, yrs297318,874
  Fatal and nonfatal CV events, n95257
  Incidence per 100 person-yrs3.201.36
  HR RA vs reference cohort
    Model 1*1.93 (1.51–2.45)1.00< 0.01
    Model 2#1.89 (1.40–2.46)1.00< 0.01
Patients with prevalent CVDΔ excluded, n2781746
  Total followup, yrs262718,008
  Fatal and nonfatal CV event, n69225
  Incidence per 100 person-yrs2.631.25
  HR RA vs reference cohort
    Model 1*1.75 (1.31–2.32)1.00< 0.01
    Model 2#1.96 (1.45–2.66)1.00< 0.01
  • * Adjusted for age and sex.

  • # Adjusted for age, sex, systolic blood pressure, antihypertensive agents, total cholesterol, high-density lipoprotein cholesterol, statins, smoking in pack-years, body mass index, diabetes mellitus, and aspirin.

  • Δ CVD according to the International Classification of Diseases criteria. CV: cardiovascular; RA: rheumatoid arthritis; CVD: CV disease.