Manifestation | FS ≥ 1, n = 167 | FS = 0, n = 51 | 0 < FS < 1, n = 11 | p | |
---|---|---|---|---|---|
> 1 vs 0 | > 1 vs < 1 | ||||
Parotid | 36 | 9 | 0 | 0.558 | 0.150 |
Submandibular | 21 | 9 | 0 | 0.349 | 0.150 |
Lymphadenopathy | 8 | 4 | 0 | 0.179 | 0.448 |
Constitutional | 50 | 22 | 3 | 0.07 | 0.174 |
Peripheral neuropathy | 51 | 14 | 4 | 0.690 | 0.230 |
Persistent cough | 50 | 17 | 3 | 0.62 | 0.264 |
Arthralgia | 105 | 42 | 8 | 0.0094 | 0.232 |
Arthritis* | 12 | 4 | 1 | 0.231 | 0.424 |
Arthritis** | 21 | 6 | 0 | 0.889 | 0.293 |
RP** | 52 | 14 | 2 | 0.633 | 0.260 |
Leukopenia | 19 | 5 | 1 | 0.763 | 0.420 |
Neutropenia | 0 | 0 | 0 | NA | NA |
Lymphopenia | 7 | 2 | 1 | 0.311 | 0.370 |
Thrombocytopenia | 2 | 1 | 0 | 0.414 | 0.822 |
Hyper IgG*** | 61 | 5 | 3 | 0.0003 | 0.114 |
Hyper IgA | 26 | 7 | 3 | 0.759 | 0.177 |
Hyper IgM | 28 | 9 | 1 | 0.883 | 0.311 |
Low C3 | 0 | 0 | 0 | NA | NA |
Low C4 | 7 | 2 | 0 | 0.311 | 0.674 |
Other antibodies | 51 | 10 | 3 | 0.133 | 0.253 |
Hypo IgG | 5 | 2 | 0 | 0.307 | 0.674 |
↵* Documented in history and physical examination by physician.
↵** Self-reported on questionnaire.
↵*** 20 g/l used as the demarcation for an elevated value because in the biological domain of the SSDAI, a serum IgG level > 20 g/l is considered positive. The biological domain is considered active if the serum IgG level is above this concentration. SSDAI: Sjögren’s Syndrome Disease Activity Index; RP: Raynaud phenomenon; NA: not applicable.