Table 2.

Comparison of patients achieving improvement in PFT with those without improvement.

VariablesPatients with Improvement, n = 79Patients without Improvement, n = 39cOR (95% CI); paOR (95% CI); p
Age at baseline evaluation, yrs, mean ± SD51.84 ± 11.8557.43 ± 9.980.95 (0.9–0.99); 0.020.96 (0.92–1.001); 0.06
Male sex18 (23)15 (38.5)0.47 (0.20–1.08); 0.080.61 (0.24–1.51); 0.29
Extent of lung disease in HRCT according to Goh score50 (38–62)52 (36–68)0.99 (0.97–1.009); 0.31
Extent of ground glass in HRCT according to Goh score41.68 (34–56)44.2 (28.2–58.2)1.002 (0.98–1.02); 0.80
Extent of fibrosis in HRCT according to Goh score5.94 (2.64–8.66)6.27 (2.88–17.92)0.97 (0.93–1.009); 0.14
Baseline % of DLCO*50.3 ± 27.555.9 ± 26.80.99 (0.97–1.007); 0.32
Baseline % of FVC53 (42–77)61 (43–80)0.99 (0.97–1.01); 0.46
Patients unable to perform baseline DLCO because of the severity of lung disease7 (9)6 (15.4)0.53 (0.16–1.71); 0.30
UIP HRCT pattern6 (7.6)9 (23)0.27 (0.09–0.83); 0.0230.46 (0.13–1.59); 0.22
Anti-Jo1 positivity34 (43)16 (41)1.08 (0.49–2.36); 0.83
Smoking history (current/former)28 (37)16 (42)0.80 (0.36–1.77); 0.58
Ro52-positive44/72 (61)20/34 (58)1.1 (0.47–2.52); 0.82
Pneumomediastinum**03 (7.6)Not estimated; p = 0.03
  • Values are n (%) unless otherwise specified. Variables with p < 0.15 in the univariate analysis were included in a multivariable logistic regression analysis to adjust for confounding.

  • * Data from 105 patients; 13 patients were unable to perform DLCO because of the severity of lung disease.

  • ** Because some cell entries were zero, the OR could not be estimated. This variable was not included in the multivariable logistic regression analysis. PFT: pulmonary function test; cOR: crude OR; aOR: adjusted OR; FVC: forced vital capacity; UIP: usual interstitial pneumonia; HRCT: high-resolution computed tomography.