Initial remission induction therapy for patients with active Takayasu arteritis.
| Medication | Total, n = 96 | Relapse, n = 57 | Nonrelapse, n = 39 | p |
|---|---|---|---|---|
| PSL dose, mg/day | 38.9 ± 14.5 | 37.0 ± 15.4 | 41.7 ± 12.9 | 0.07 |
| PSL dose, mg/kg/day | 0.72 ± 0.28 | 0.66 ± 0.31 | 0.79 ± 0.25 | 0.02 |
| Reduction rate of PSL, mg/month | 2.1 ± 3.3 | 2.8 ± 3.8 | 1.0 ± 1.9 | < 0.0001 |
| Above 30 mg, mg/week | 3.2 ± 1.4 | 3.0 ± 1.1 | 3.1 ± 0.9 | 0.52 |
| 30 to 20 mg, mg/week | 2.5 ± 0.9 | 2.4 ± 1.0 | 2.7 ± 0.9 | 0.27 |
| Below 20 mg/day, mg/month | 1.3 ± 1.0 | 1.7 ± 1.3 | 0.8 ± 0.6 | 0.005 |
| Immunosuppressants | 32 (33.3) | 17 (29.8) | 15 (38.5) | 0.38 |
| MTX | 24 (75.0) | 13 (76.5) | 11 (73.3) | 0.99 |
| MZR | 3 (9.4) | 2 (11.8) | 1 (6.7) | 0.99 |
| IVCYC | 2 (6.3) | 1 (5.9) | 1 (6.7) | 0.99 |
| CSA | 1 (3.1) | 1 (5.9) | 0 (0) | 0.99 |
| AZA | 1 (3.1) | 0 (0) | 1 (6.7) | 0.47 |
| TAC | 1 (3.1) | 0 (0) | 1 (6.7) | 0.47 |
Values are mean ± SD or number (%). AZA: azathioprine; CSA: cyclosporine; IVCYC: intravenous cyclophosphamide; MTX: methotrexate; MZR: mizoribine; PSL: prednisolone; TAC: tacrolimus.