Comparison of 1-year and 2-year change in cartilage thickness from baseline in the biomarkers set.
| 1-year Change from Baseline | 2-year Change from Baseline | ||||||
|---|---|---|---|---|---|---|---|
| FNIH Biomarkers Group | Mean Change (95% CI) | SRM (95% CI) | p | Mean Change (95% CI) | SRM (95% CI) | p | |
| Femur Change (cMF Region) | |||||||
| All | Manual | −0.031 (−0.022, −0.039) | −0.31 (−0.23, −0.38) | 5.797E-13 | −0.071 (−0.058, −0.085) | −0.43 (−0.36, −0.49) | 9.72E-23 |
| All | Automated | −0.059 (−0.047, −0.071) | −0.41 (−0.34, −0.48) | 8.330E-22 | −0.14 (−0.123, −0.157) | −0.67 (−0.6, −0.72) | 2.54E-48 |
| JSN | Manual | −0.059 (−0.033, −0.084) | −0.45 (−0.28, −0.6) | 1.320E-05 | −0.136 (−0.099, −0.173) | −0.74 (−0.59, −0.89) | 4.07E-11 |
| JSN | Automated | −0.092 (−0.056, −0.128) | −0.5 (−0.32, −0.67) | 1.620E-06 | −0.236 (−0.184, −0.288) | −0.9 (−0.73, −1.05) | 9.10E-15 |
| JSN and Pain | Manual | −0.055 (−0.039, −0.07) | −0.5 (−0.34, −0.63) | 1.228E-10 | −0.128 (−0.102, −0.154) | −0.73 (−0.62, −0.83) | 9.72E-23 |
| JSN and Pain | Automated | −0.074 (−0.052, −0.097) | −0.48 (−0.36, 0.6) | 8.330E-22 | −0.209 (−0.177, −0.241) | −0.96 (−0.82, −1.09) | 2.54E-48 |
| Pain | Manual | −0.008 (0.009, −0.026) | −0.1 (0.1, −0.28) | 3.398E-01 | −0.023 (0.017, −0.063) | −0.12 (0.08, −0.24) | 2.63E-01 |
| Pain | Automated | −0.036 (−0.016, −0.057) | −0.35 (−0.16, −0.52) | 6.703E-04 | −0.04 (−0.012, −0.068) | −0.28 (−0.06, −0.43) | 5.97E-03 |
| Nonprogressors | Manual | −0.005 (0.004, −0.014) | −0.07 (0.07, −0.21) | 3.057E-01 | −0.01 (0.001, −0.021) | −0.13 (0.01, −0.27) | 7.98E-02 |
| Nonprogressors | Automated | −0.039 (−0.023, −0.056) | −0.33 (−0.2, −0.45) | 6.924E-06 | −0.077 (−0.056, −0.098) | −0.52 (−0.4, −0.62) | 1.14E-11 |
| Tibia Change (cMT Region) | |||||||
| All | Manual | −0.036 (−0.026, −0.045) | −0.3 (−0.23, −0.38) | 2.264E-12 | −0.073 (−0.059, −0.086) | −0.43 (−0.35, −0.49) | 1.14E-22 |
| All | Automated | −0.055 (−0.043, −0.067) | −0.39 (−0.31, −0.45) | 1.829E-19 | −0.114 (−0.097, −0.131) | −0.55 (−0.48, −0.61) | 3.21E-35 |
| JSN | Manual | −0.057 (−0.03, −0.084) | −0.42 (−0.22, −0.6) | 4.223E-05 | −0.117 (−0.083, −0.15) | −0.7 (−0.52, −0.85) | 3.17E-10 |
| JSN | Automated | −0.08 (−0.05, −0.11) | −0.52 (−0.33, −0.72) | 7.201E-07 | −0.179 (−0.132, −0.225) | −0.76 (−0.58, −0.91) | 1.43E-11 |
| JSN and Pain | Manual | −0.05 (−0.03, −0.07) | −0.37 (−0.23, −0.49) | 1.287E-06 | −0.117 (−0.088, −0.146) | −0.6 (−0.47, −0.7) | 1.14E-22 |
| JSN and Pain | Automated | −0.068 (−0.043, −0.093) | −0.4 (−0.26, −0.51) | 1.829E-19 | −0.172 (−0.137, −0.207) | −0.72 (−0.6, −0.82) | 3.21E-35 |
| Pain | Manual | −0.025 (−0.006, −0.045) | −0.26 (−0.06, −0.45) | 9.860E-03 | −0.03 (0.009, −0.069) | −0.16 (0.07, −0.26) | 1.23E-01 |
| Pain | Automated | −0.037 (−0.018, −0.057) | −0.38 (−0.2, −0.54) | 2.170E-04 | −0.035 (−0.008, −0.062) | −0.26 (−0.06, −0.42) | 1.05E-02 |
| Nonprogressors | Manual | −0.016 (−0.002, −0.031) | −0.16 (−0.03, −0.31) | 2.792E-02 | −0.03 (−0.015, −0.045) | −0.29 (−0.15, −0.44) | 9.56E-05 |
| Nonprogressors | Automated | −0.039 (−0.022, −0.056) | −0.32 (−0.19, −0.44) | 1.056E-05 | −0.067 (−0.044, −0.089) | −0.42 (−0.3, −0.52) | 2.01E-08 |
Results are shown for all 582 knees (“All”), together with the 4 subgroups: joint space narrowing progressors (“JSN”, n = 102), both JSN and pain progressors (“JSN and Pain”, n = 183), pain progressors (“Pain”, n = 101), and nonprogressors (“Nonprogressors”, n = 196). SRM 95% CI were estimated using a bootstrap method. JSN: joint space narrowing; FNIH: US Foundation for the National Institutes of Health; SRM: standardized response means; cMF: central medial femur.