Variables | Cohort 1, 1975–1987 | Cohort 2, 1999–2011 | p |
---|---|---|---|
No. patients | 234 | 262 | NA |
Age at enrollment, yrs | 35.4 ± 15.2 | 36.1 ± 13.8 | 0.62 |
Sex, female | 205 (87.6) | 232 (88.5) | 0.75 |
Ethnicity | < 0.001 | ||
Black | 19 (8.1) | 52 (19.8) | |
White | 199 (85.0) | 135 (51.5) | |
Chinese | 11 (4.7) | 31 (11.8) | |
Filipino | 2 (0.9) | 16 (6.1) | |
Others | 3 (1.3) | 28 (10.7) | |
Disease duration at enrollment, mos | 2.9 ± 3.5 | 2.6 ± 3.0 | 0.31 |
SLEDAI-2K at enrollment | 10.0 ± 9.0 | 9.8 ± 7.8 | 0.81 |
Nephritis | 75 (32.1) | 71 (27.1) | 0.23 |
Vasculitis | 33 (14.1) | 23 (8.8) | 0.06 |
Corticosteroids | 114 (48.7) | 163 (62.2) | 0.003 |
Corticosteroid dose, mg/day | 33.4 ± 28.7 | 30.6 ± 20.3 | 0.34 |
Antimalarials | 44 (18.8) | 117 (44.7) | < 0.001 |
Immunosuppressives | 12 (5.1) | 61 (23.3) | < 0.001 |
Hypertension | 41 (17.5) | 70 (26.7) | 0.01 |
Hypercholesterolemia | 70 (29.9) | 108 (41.2) | 0.009 |
Diabetes | 2 (0.9) | 9 (3.4) | 0.05 |
Smoking | 56 (24.1) | 37 (14.4) | 0.006 |
Values are n (%) or mean ± SD unless otherwise specified. SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index 2000; NA: not applicable.