Interventions during the first 17 years of followup.
| Intervention | Cohort 1, 1975–1987 | Cohort 2, 1999–2011 | p |
|---|---|---|---|
| No. patients | 234 | 262 | |
| Antihypertensives | 29 (12.4) | 124 (47.3) | 0.0001 |
| Lipid-lowering agents | 4 (1.7)* | 63 (24) | < 0.0001 |
| Diabetes | 11 (4.7) | 18 (6.9) | 0.30 |
| Smoking | 80 (34.2) | 54 (20.6) | 0.0007 |
| Ever treated with steroids | 161 (68.8) | 214 (81.7) | 0.001 |
| Average steroid dose, mg/day | 17.6 ± 14.6 | 12.3 ± 8.5 | 0.001 |
| Ever treated with antimalarials | 114 (48.7) | 241 (92.0) | 0.001 |
| Ever treated with immunosuppressives | 67 (28.6) | 178 (67.9) | 0.001 |
Values are n (%) or mean ± SD unless otherwise specified.
↵* Earliest recorded use: May 1986.