Visits in remission according to different definitions of remission*.
| Definition of Remission | Patients in Remission at First METEOR Visit, n (%) | Visits in Remission, Taking All Visits into Account, n (%) | |||
|---|---|---|---|---|---|
| N1 | N2 | ||||
| ACR/EULAR Boolean-based | 279 (1.9) | 14,696 | 2465 (4.5) | 55,261 | |
| SDAI ≤ 3.3 | 705 (6.1) | 11,562 | 7072 (17.1) | 41,420 | |
| CDAI ≤ 2.8 | 1188 (7.6) | 15,682 | 9579 (13.4) | 71,790 | |
| DAS-CRP < 1.6 | 4v | 2093 (16.0) | 13,067 | 19,481 (38.6) | 50,517 |
| 3v | 2688 (15.5) | 17,352 | 23,924 (39.1) | 61,214 | |
| DAS-ESR < 1.6 | 4v | 3699 (20.4) | 18,170 | 29,256 (31.7) | 92,164 |
| 3v | 4238 (18.6) | 22,780 | 33,774 (30.4) | 111,149 | |
| DAS28-CRP < 2.6 | 4v | 2326 (15.8) | 14,696 | 19,252 (34.8) | 55,261 |
| 3v | 3097 (16.3) | 19,049 | 24,742 (37.5) | 65,944 | |
| DAS28-ESR < 2.6 | 4v | 3295 (16.1) | 20,497 | 24,895 (25.2) | 98,629 |
| 3v | 3765 (14.9) | 25,235 | 28,647 (24.4) | 117,404 | |
| DAS28-CRP < 1.9** | 4v | 1020 (6.9) | 14,696 | 9328 (16.9) | 55,261 |
| 3v | 1235 (6.5) | 19,049 | 11,503 (17.4) | 65,944 | |
| DAS28-ESR < 2.2** | 4v | 2032 (9.9) | 20,497 | 15,922 (16.1) | 98,629 |
| 3v | 2032 (8.8) | 25,235 | 17,875 (15.2) | 117,404 | |
| DAS28-CRP < 2.4** | 4v | 1960 (13.3) | 14,696 | 16,716 (30.2) | 55,261 |
| 3v | 2657 (13.9) | 19,049 | 21,500 (32.5) | 65,944 | |
↵* Results at the first METEOR visit and taking all visits into account.
↵** DAS28 formulae with the newly suggested cutoffs [DAS28-CRP < 1.9 (calculated vs SDAI), DAS28-ESR < 2.2 (calculated vs SDAI), and DAS28-CRP < 2.4 (calculated vs DAS28-ESR)]. ACR: American College of Rheumatology; EULAR: European League Against Rheumatism; CDAI: Clinical Disease Activity Index; CRP: C-reactive protein; DAS: Disease Activity Score; DAS28: 28-joint count DAS; ESR: erythrocyte sedimentation rate; METEOR: Measurement of Efficacy of Treatment in the Era of Outcome in Rheumatology; N1 and N2: no. visits with information available; SDAI: Simplified Disease Activity Index; 3v: 3 variables; 4v: 4 variables.