Outcomes.
| Variables | Cohort 1, 1975–1987 | Cohort 2, 1999–2011 | p |
|---|---|---|---|
| No. patients | 234 | 262 | NA |
| Followup time, yrs | 6.6 ± 4.8 | 8.3 ± 4.7 | < 0.001 |
| PY of followup | 1480.0 | 2288.0 | |
| Outcomes | |||
| No. AVE, n (%) | 26 (11.1) | 10 (3.8) | 0.001 |
| MI | 7 | 3 | |
| Angina | 8 | 2 | |
| CHF | 8 | 1 | |
| Bradyarrhythmia requiring pacemaker | 0 | 1 | |
| Stroke | 3 | 1 | |
| TIA | 0 | 3 | |
| Yrs from enrollment to AVE | 4.2 ± 5.0 | 5.9 ± 4.2 | NS |
| Median age at first AVE, yrs | 48.2 | 56.9 | NS |
| Incidence of AVE per 100 PY | 1.8 | 0.44 | < 0.001 |
| Classic risk factors, % | |||
| Percent yrs with normal BP | 72.0 | 86.7 | 0.0001 |
| Percent yrs with normal cholesterol | 39.6 | 72.3 | 0.0001 |
| Percent yrs with normal glucose | 84.8 | 93.2 | 0.0001 |
| Percent of yrs smoked | 24.7 | 11.3 | 0.0001 |
| Disease-related factors | |||
| AMS within 5 yrs of enrollment | 5.7 ± 5.2 | 4.5 ± 3.4 | 0.003 |
| Alive at end of 17 yrs of followup, n (%) | 183 (78.2) | 247 (94.3) | < 0.001 |
Values are mean ± SD unless otherwise specified. PY: person-years; AVE: atherosclerotic vascular events; MI: myocardial infarction; CHF: congestive heart failure; TIA: transient ischemic attack; BP: blood pressure; AMS: adjusted mean SLEDAI-2K; SLEDAI-2K: Systemic Lupus Erythematosus Disease Activity Index 2000; NA: not applicable; NS: not significant.