Table 2.

Renal histological features in lupus nephritis (LN) patients with or without thrombotic microangiopathy on kidney biopsy.

Renal Histological FeaturesWith Renal TMA, n = 24Without Renal TMA (controls), n = 48p
Class of LN on presentation
  Class III or IV19 (79.2)38 (79.2)1.000
  Class III + V or IV + V4 (16.6)8 (16.6)1.000
  Class V1 (4.2)2 (4.2)1.000
Accompanying renal histological features
  Activity index11 (2–19)7 (0–15)0.004
    Endocapillary proliferation3 (1–3)3 (1–3)0.349
    Leukocyte infiltration1 (0–3)0 (0–3)0.005
    Fibrinoid necrosis/karryorrhexis1 (0–2)0 (0–6)0.011
    Cellular crescents1 (0–3)0 (0–6)0.079
    Hyaline thrombi/wire loops1 (0–3)1 (0–3)0.489
    Mononuclear cell infiltrates1 (0–3)1 (0–1)< 0.001
  Chronicity index3 (1–8)1 (0–3)< 0.001
    Glomerulosclerosis1 (0–2)0 (0–3)0.979
    Fibrous crescents0 (0–1)0 (0–1)0.050
    Interstitial fibrosis1 (0–3)0 (0–3)< 0.001
    Tubular atrophy1 (0–3)0 (0–3)< 0.001
  • Values are n (%) or median (range). TMA: thrombotic microangiopathy.