Patients with IIM | General Population | |||||||
---|---|---|---|---|---|---|---|---|
ACS, n | F/U, PY | Rate (95% CI)† | ACS, n | F/U, PY | Rate (95% CI) † | RD (95% CI) | HR (95% CI) | |
ACS | 53 | 3402 | 15.6 (11.7–20.4) | 313 | 41,783 | 7.5 (6.7– 8.4) | 5.7 (2.2–9.3) | 2.4 (1.8–3.2) |
UA | 2 | 3402 | 0.6 (0.1–2.1) | 28 | 41,783 | 0.7 (0.4–1.0) | −0.2 (−0.5 to 0.1) | 0.9 (0.2–3.7) |
NSTEMI | 17 | 3402 | 5.0 (2.9–8.0) | 103 | 41,783 | 2.5 (2.0–3.0) | 1.8 (−0.1 to 3.8) | 2.3 (1.4–3.9) |
STEMI | 34 | 3402 | 10 (6.9–14.0) | 182 | 41,783 | 4.4 (3.7–5.0) | 4.0 (1.2–6.8) | 2.8 (1.9–4.0) |
Sex | ||||||||
Female | 30 | 1934 | 15.5 (10.5–22.1) | 136 | 24,179 | 5.6 (4.7– 6.7) | 7.4 (2.6–12.2) | 3.4 (2.3–5.0) |
Male | 23 | 1469 | 15.7 (9.9–23.5) | 177 | 17,604 | 10.1 (8.6–11.7) | 3.9 (−1.4 to 9.2) | 1.8 (1.2–2.8) |
Age group, yrs | ||||||||
< 56 | 7 | 1424 | 4.9 (2.0–10.1) | 33 | 15,447 | 2.1 (1.5– 3.0) | 2.7 (−0.9 to 6.3) | 2.4 (1.1–5.5) |
56–67 | 11 | 1145 | 9.6 (4.8–17.2) | 84 | 13,870 | 6.1 (4.8– 7.5) | 4.0 (−1.8 to 9.9) | 1.6 (0.8–3.0) |
68–90 | 35 | 834 | 42 (29.2–58.4) | 196 | 12,466 | 15.7 (13.6–18.1) | 26.5 (12.5–40.6) | 2.8 (1.9–4.1) |
Subset | ||||||||
DM | 8 | 1066 | 7.5 (3.2–14.8) | 85 | 13,498 | 6.3 (5.0– 7.8) | 1.4 (−4.0 to 6.8) | 1.2 (0.6–2.5) |
Other IIM | 45 | 2337 | 19.3 (14.0–25.8) | 228 | 28,276 | 8.1 (7.1– 9.2) | 11.4 (5.7–17.1) | 2.5 (1.8–3.4) |
↵† Incidence rate per 1000 PY, CI estimated using a Poisson distribution. HR estimated by Cox models adjusted for age, sex, and county of residence at index year. Rate differences (RD) estimated using a Poisson model adjusted for age (tertiles) and sex. IIM: idiopathic inflammatory myopathy; F/U: followup; ACS: acute coronary syndrome; UA: unstable angina; STEMI: ST-elevation myocardial infarction; NSTEMI: non-STEMI; DM: dermatomyositis; PY: person-years.