Relationship between demographic and health-related variables assessed at 19-year followup and physical HRQOL measured by the SF-12 PCS in 96 patients with JIA.
| Variables | Physical HRQOL (SF-12 PCS) after 19 Years | |||
|---|---|---|---|---|
| Univariate Analysis | Multiple Regression Analysis * | |||
| Variables assessed at 19-yr followup | B† (95% CI) | p | B† (95% CI) | p |
| Patient demographics | ||||
| Female sex# | 0.5 (−3.8, 4.8) | 0.81 | ||
| Age, yrs | 0.2 (−0.2, 0.7) | 0.34 | ||
| Patient-reported outcomes | ||||
| Mental HRQOL (SF-12 MCS) | −0.1 (−0.3, 0.1) | 0.55 | ||
| Physical limitations (HAQ-DI > 0, range 0–3) # | −11.0 (−14.4, −7.6) | < 0.001 | −5.3 (−8.3, −2.2) | 0.001 |
| Pain intensity (VAS pain, range 0–10) | −2.5 (−3.0, −2.0) | < 0.001 | −2.0 (−2.6, −1.5) | < 0.001 |
| Fatigue (VAS, range 0–10) | −1.6 (−2.2, −0.5) | < 0.001 | ||
| Overall well-being (VAS, range 0–10) | −2.4 (−3.0, −1.8) | < 0.001 | ||
| Anxiety and depression (SCL-5, range 0–4) | −2.4 (−5.2, −0.4) | 0.09 | ||
| Clinical disease characteristics | ||||
| No. active joints, self-reported | −0.6 (−1.0, −0.2) | 0.002 | ||
| Current use of DMARD # | −2.9 (−6.8, −1.1) | 0.10 | ||
| Daily stiffness duration > 10 min | −8.5 (−12.1, −5.0) | < 0.001 | ||
↵* Results from the final model of multiple linear regression analysis (backward regression method), R2 = 58%.
↵† B: unstandardized regression coefficient.
↵# Dichotomized variables. Brief Pain Inventory (pain intensity and pain interference) are not included in the analysis owing to multicollinearity with each other and with pain intensity (VAS pain). HRQOL: health-related quality of life; SF-12: SF-12v2 Health Survey; MCS: mental component summary; PCS: physical component summary; HAQ-DI: Health Assessment Questionnaire–Disability Index; VAS: visual analog scale; overall well-being: patient’s global assessment of overall well-being; SCL-5: Hopkins Symptom Checklist 5; DMARD: disease-modifying antirheumatic drug.