Percentage frequency of reported domains and complete adoption of the core outcome set in included trial registrations.
| Domain | Percentage Total | Percentage Frequency by Year | ||||
|---|---|---|---|---|---|---|
| Frequency, n = 382 | 1997–2001, n = 18 | 2002–2006, n = 94 | 2007–2011, n = 133 | 2012–2016, n = 123 | 2017, n = 14 | |
| Core domain | ||||||
| Pain | 94.8 | 100 | 91.5 | 96.9 | 94.4 | 92.9 |
| Physical function | 86.1 | 94.4 | 81.9 | 89.2 | 84.1 | 92.9 |
| Patient’s global assessment | 47.6 | 66.7 | 59.6 | 45.4 | 38.1 | 42.9 |
| Imaging* | 75.0 | 71.4 | 40.0 | 79.2 | 89.5 | 85.7 |
| All core domains measured | 45.3 | 61.1 | 54.3 | 43.1 | 38.1 | 50.0 |
| Recommended domains | ||||||
| HRQOL | 26.2 | 27.8 | 12.8 | 39.1 | 27.6 | 14.3 |
| Clinician global assessment | 23.0 | 44.4 | 36.2 | 16.5 | 20.3 | 14.3 |
| Optional domains | ||||||
| Stiffness | 58.1 | 66.7 | 58.5 | 64.7 | 52.0 | 35.7 |
| Biological markers, i.e., relevant blood tests | 18.8 | 22.2 | 17.0 | 23.3 | 15.4 | 7.1 |
| Swelling | 7.1 | 16.7 | 3.2 | 6.8 | 8.1 | 7.1 |
| Performance assessment | 14.7 | 27.8 | 11.7 | 15.0 | 16.3 | 7.1 |
| Pain flares | 1.6 | 5.6 | 3.2 | 1.5 | 0.8 | 0.0 |
| Time to surgery | 2.6 | 16.7 | 0.0 | 0.0 | 4.1 | 7.1 |
| Analgesic consumption | 27.0 | 50.0 | 29.8 | 24.8 | 22.8 | 21.4 |
↵* Imaging is a required core outcome set domain for trials of 12 months or greater followup in trials of structure-modifying osteoarthritis drugs (total n = 68). HRQOL: health-related quality of life.