Table 4.

Results of Delphi round 3 and domain placement in OMERACT Onion Framework after consensus voting.

Variables	Patients/Parents			Other Stakeholders			Average of Sums ^⁵
Variables	Inner	Middle	Sum	Inner	Middle	Sum	Average of Sums ^⁵
Mandatory domains (inner circle/core set)
Pain¹	88			67			77
Joint inflammatory signs/active joints¹	50			89			70
Side effects/adverse events^²	63			58			60
Activity limitation/physical function³	76	18	94	79	19	98	96
Patient’s perception of disease/overall well-being^⁴	32	56	88	66	25	91	90
Important but optional domains (middle circle)
Joint damage	71	25	96	41	50	91	93
Laboratory signs of inflammation (acute-phase reactants)	53	37	90	82	16	96	93
Eye inflammation	47	47	94	62	36	98	96
Inflammatory signs outside joints/eyes	46	44	90	66	34	100	95
Physician’s perception of disease activity	32	52	84	83	14	97	90
Stiffness	46	48	94	46	44	91	92
Growth and maturation	28	54	82	23	64	87	85
Participation restriction	30	56	86	24	55	78	82
Imaging signs of inflammation	25	58	84	25	55	79	81
Physical activity (exercise)	16	73	89	3	62	65	77
Fatigue	42	52	94	5	54	58	76
Effect on emotional function, mood, cognition	42	47	89	8	45	54	71
Research agenda (outer circle)
Coping with illness	20	61	81	5	49	54	67
Healthcare use	24	53	77	4	36	40	58
Sleep	8	67	75	0	40	40	57
Effect on social relationships	13	56	68	1	32	33	51
Personal factors	14	56	70	1	30	31	51

↵1 Domains voted into inner circle with round 1 of Delphi.
↵2 Side effects/adverse events is a mandatory domain for all clinical trials per OMERACT Handbook.
↵3 Domain placement rules for Delphi round 3 based on percent votes for inner circle and middle circle: if average of inner circle votes for both stakeholder groups > 70% recommend inner circle. If sum of inner circle plus middle circle votes > 70% for both stakeholder groups (but average of inner circle votes alone is not > 70%), recommend middle circle. If sum of inner circle and middle circle votes > 70% for only 1 stakeholder group, but average > 70%, then consider middle circle. If sum of inner circle and middle circle votes > 70% for only 1 or none of the stakeholder groups, and average < 70%, then recommend outer circle.
↵4 Inclusion of patient’s perception of disease/overall well-being in inner circle based on OMERACT workshop voting does not follow suggested domain placement rules. See text.
↵5 “Average of sums” is average of inner circle plus middle circle votes for both stakeholder groups from Delphi round 3. The sums do not add to 100 because of exclusion of the votes for outer circle from presentation in the table. OMERACT: Outcome Measures in Rheumatology.