Listing of entry criteria and additive criteria after the nominal group technique exercise.
| Criteria |
|---|
| Entry criteria |
| Antinuclear antibody by HEp-2 immunofluorescence ≥ 1:80 |
| Low C3 and/or low C4 |
| Additive criteria |
| Lupus nephritis by renal biopsy with immune deposits |
| Rash with dermoepidermal interface changes and/or Ig and/or complement deposition on immunofluorescence |
| Anti-dsDNA antibody |
| Anti-Sm antibody |
| Presence of multiple autoantibodies* |
| aPL (LAC, aCL, anti-β2–glycoprotein 1, or prolonged Russell’s viper venom time) |
| Leukopenia (< 4000/mm3 on 2 or more occasions) |
| Thrombocytopenia < 100,000 on 2 or more occasions |
| Autoimmune hemolytic anemia |
| Active urine sediment (without urinary tract infection) |
| Persistent proteinuria (≥ 0.5 g/day) |
| Acute cutaneous lupus: SLICC definition (includes subacute cutaneous lupus) |
| Chronic cutaneous lupus: SLICC definition |
| Alopecia with associated scalp inflammation |
| Arthritis* |
| Serositis (pleural, pericardial effusion, pleurisy, pericarditis, peritonitis) |
| Oral mucosal lesions on the hard palate |
| CNS manifestations (seizures, psychosis, chorea, myelitis, optic neuritis, stroke or acute confusional state) |
| Fever* |
↵* To be defined. SLICC: Systemic Lupus International Collaborating Clinics; CNS: central nervous system; aPL: antiphospholipid antibodies; LAC: lupus anticoagulant; aCL: anticardiolipin.