Mean autoantibody (anti-CCP) concentrations across haplotype groups and by HLA-DRB1 status.
| Haplotype | All, n = 1441 | Anti-CCP+, n = 1113 | ||||
|---|---|---|---|---|---|---|
| Haplotype+ | Haplotype− | p* | Haplotype+ | Haplotype− | p | |
| VKA | 331 (510) | 243 (407) | < 0.001 | 377 (529) | 338 (445) | 0.09 |
| VRA | 303 (449) | 261 (445) | < 0.001 | 360 (468) | 350 (484) | 0.88 |
| LRA | 311 (485) | 259 (431) | 0.02 | 389 (514) | 340 (466) | 0.03 |
| PRA | 291 (295) | 272 (450) | 0.18 | 342 (291) | 353 (484) | 0.44 |
| VRE | 267 (488) | 273 (445) | 0.37 | 368 (542) | 292 (357) | 0.60 |
| DRE | 156 (218) | 278 (453) | 0.79 | 184 (226) | 361 (487) | 0.003 |
| VEA | 136 (164) | 274 (448) | 0.29 | 213 (160) | 354 (481) | 0.76 |
| SKA | 258 (304) | 273 (451) | 0.47 | 321 (308) | 354 (485) | 0.44 |
| PAA | 323 (478) | 260 (438) | 0.13 | 413 (505) | 338 (472) | 0.02 |
| GRQ | 275 (502) | 272 (435) | 0.35 | 369 (551) | 350 (465) | 0.95 |
| SRA | 244 (431) | 277 (449) | 0.01 | 351 (479) | 353 (480) | 0.72 |
| SRE | 211 (398) | 275 (448) | 0.006 | 366 (470) | 353 (480) | 0.87 |
| LEA | 126 (167) | 275 (449) | 0.02 | 229 (165) | 354 (481) | 0.65 |
| SRL | 258 (397) | 273 (449) | 0.50 | 352 (426) | 353 (482) | 0.90 |
| SKR | 155 (336) | 296 (461) | < 0.001 | 259 (404) | 367 (488) | < 0.001 |
| SEA | 191 (360) | 287 (459) | < 0.001 | 284 (408) | 364 (489) | 0.003 |
| Valine 11 | 303 (479) | 233 (397) | < 0.001 | 359 (501) | 343 (441) | 0.59 |
| SE | 310 (477) | 178 (342) | < 0.001 | 375 (500) | 281 (394) | < 0.001 |
Data are expressed as IU/ml, mean ± SD.
↵* P value by independent t tests after natural log transformation of autoantibody concentrations. Significant p values are shown in bold face. RF: rheumatoid factor; CCP: cyclic citrullinated peptides; SE: shared epitope.