Table 1.

Premeeting ranking of 43 candidate criteria.

ItemRanking, Median (Range)
Premeeting ranking of ANA and complement criteria
  ANA on HEp-2 cells with a pattern compatible with SLE, titer ≥ 1:1601.5 (1–5)
  ANA-positive (any pattern) ≥ 1:1602 (1–5)
  Low C3 and C43 (1–5)
  ANA-positive by HEp-23 (1–5)
  Low C33.5 (2–5)
Premeeting ranking of 38 candidate additive criteria
  Lupus nephritis by renal biopsy with immune deposits1 (1–2)
  Anti-dsDNA antibody2 (1–8)
  Anti-Sm antibody3 (1–18)
  Glomerulonephritis (dysmorphic urinary red blood cells or urinary red blood cell casts (≥ 1 cast/high-powered field)6 (1–35)
  Acute, subacute, or chronic lupus rash (can include malar, discoid, subacute cutaneous lupus)6 (1–32)
  Rash with dermoepidermal interface changes and Ig and/or complement deposition on immunofluorescence8 (1–36)
  Persistent proteinuria (> 0.5 g/day)9 (2–36)
  Malar rash11 (1–25)
  Active urine sediment (without urinary tract infection)12 (1–38)
  Serositis (clinical signs, or pleural or pericardial effusion by imaging)12 (2–23)
  Arthritis13 (2–33)
  Presence of multiple autoantibodies14 (1–37)
  CNS dysfunction (seizures, psychosis, chorea, myelitis, optic neuritis, stroke, or acute confusional state)14 (3–31)
  Urinary red blood cell casts (≥ 1 cast/hpf)16 (2–36)
  Oral mucosal lesions on the hard palate17 (2–30)
  Thrombocytopenia17 (2–36)
  Leukopenia (< 4000/mm3 on 2 or more occasions)17 (3–37)
  Antiphospholipid antibodies (lupus anticoagulant, anticardiolipin, anti-β2–glycoprotein 1, or prolonged Russell’s viper venom time)17.5 (2–33)
  Thrombocytopenia (severe)18 (1–32)
  Autoimmune hemolytic anemia18 (1–34)
  Photosensitive rash19 (2–30)
  Antiphospholipid antibody syndrome (clinical signs/history + antibodies)19 (2–38)
  Urine cellular casts20 (2–37)
  Discoid rash20 (3–26)
  Lymphopenia (< 1500/mm3 on 2 or more occasions)20 (3–36)
  Positive lupus anticoagulant panel21 (2–34)
  Pleural effusion23 (2–36)
  Pleuritis23 (2–33)
  Subacute cutaneous lupus erythematosus24 (3–33)
  Alopecia with associated scalp inflammation24.5 (3–38)
  Pericardial effusion25 (2–37)
  Photosensitivity27 (3–34)
  Raynaud phenomenon27 (3–35)
  Fever28 (2–37)
  Lupus profundus28 (3–38)
  Lymphopenia (< 1000/mm3 on 2 or more occasions)29 (3–37)
  Arthralgia32 (3–37)
  Fatigue35 (4–38)
  • The ANA and complement criteria comprise 5 of 43 candidate criteria. The candidate additive criteria comprise 38 of 43 candidate criteria. ANA: antinuclear antibody; SLE: systemic lupus erythematosus; CNS: central nervous system.