Traditional cardiovascular risk factors in juvenile MCTD patients and controls.
| Variables | Patients, n = 50 | Controls, n = 50 | p |
|---|---|---|---|
| BMI, kg/m2, mean (SD) | 22.8 (3.5) | 23.5 (3.0) | 0.279 |
| Height, cm, mean (SD) | 166.0 (7.5) | 169.6 (8.6) | 0.022 |
| Weight, kg, mean (SD) | 63.0 (12.3) | 67.9 (12.4) | 0.046 |
| Current smokers, n (%) | 7 (14.3) | 9 (18.4) | 0.785 |
| Daily smokers, n (%) | 1 (2.0) | 2 (4.1) | 1.000 |
| Ever smokers, n (%) | 15 (30.6) | 17 (34.7) | 0.830 |
| Vigorous physical activity, h/week | 2.0 (0.8–4.0) | 2.0 (0.3–5.1) | 0.391 |
| Moderate physical activity, h/week | 2.0 (0.8–5.5) | 1.3 (0.4–4.6) | 0.338 |
| Hypertension, n (%) | 1 (2) | 0 (0) | 1.00 |
| SBP, mmHg, mean (SD) | 111.9 (14.5) | 114.8 (11.9) | 0.233 |
| SBP ≥ 140 mmHg, n (%) | 1 (2.1) | 0 (0) | 0.495 |
| DBP, mmHg, mean (SD) | 64.8 (15.0) | 67.9 (8.6) | 0.177 |
| LDL cholesterol, mmol/l, mean (SD) | 2.43 (0.67) | 2.83 (0.93) | 0.027 |
| HDL cholesterol, mmol/l, mean (SD) | 1.31 (0.35) | 1.65 (0.44) | < 0.001 |
| HDL/LDL ratio | 0.54 | 0.58 | 0.184 |
| TG, mmol/l | 0.85 (0.70–1.15) | 0.70 (0.60–0.90) | 0.115 |
| ApoA-I, mg/l | 1.40 (1.10–1.70) | 1.60 (1.50–1.80) | < 0.001 |
| ApoB, mg/l | 0.70 (0.70–0.90) | 0.80 (0.70–1.0) | 0.158 |
| ApoB/ApoA-I ratio | 0.53 (0.46–0.63) | 0.50(0.41–0.60) | 0.328 |
| Glucose, mmol/l, mean (SD) | 4.84 (0.93) | 5.06 (0.43) | 0.106 |
| HbA1c, % | 5.30 (5.10–5.50) | 5.20 (4.95–5.45) | 0.071 |
| CRP, mg/l (41 pairs) | 0.62 (0.50–2.50) | 0.60 (0.50–0.90) | 0.108 |
| ESR, mm/h | 9.0 (5.0–16.0) | 4.0 (2.0–7.0) | < 0.001 |
Values are median (IQR) unless otherwise specified. Values in bold face are statistically significant. MCTD: mixed connective tissue disease; BMI: body mass index; SBP: systolic blood pressure; DBP; diastolic blood pressure; HDL: high-density lipoprotein; LDL: low-density lipoprotein; TG: triglycerides; ApoA-I: apolipoprotein A-I; ApoB: apolipoprotein B; HbA1c: glycosylated hemoglobin; CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; IQR: interquartile range.