Demographic characteristics and comorbidities of PsA by severity.
| Characteristics | Mild PsA, n = 5611 | Moderate PsA, n = 3479 | Severe PsA, n = 1487 | p |
|---|---|---|---|---|
| Age, yrs, mean (SD) | 57.0 (14.5) | 57.9 (13.6) | 53.7 (12.8) | < 0.001 |
| Women | 3278 (58.4) | 2080 (59.8) | 810 (54.5) | 0.002 |
| Men | 2333 (41.6) | 1399 (40.2) | 677 (45.5) | |
| Socioeconomic status | < 0.001 | |||
| Lowest | 308 (5.5) | 154 (4.4) | 68 (4.6) | |
| Below average | 1329 (23.7) | 900 (25.9) | 277 (18.6) | |
| Average | 1440 (25.7) | 964 (27.7) | 402 (27.0) | |
| Above average | 1322 (23.6) | 816 (23.5) | 398 (26.8) | |
| Highest | 1212 (21.6) | 645 (18.5) | 342 (23.0) | |
| Time since diagnosis, yrs, mean (SD) | 8.9 (7.0) | 10.1 (6.2) | 10.5 (6.0) | < 0.001 |
| Smoking | 945 (16.8) | 592 (17.0) | 233 (15.7) | 0.483 |
| Alcohol abuse | 415 (7.4) | 200 (5.8) | 89 (6.0) | 0.005 |
| Hypertension | 488 (8.7) | 310 (8.9) | 112 (7.5) | 0.266 |
| Diabetes | 631 (11.3) | 426 (12.2) | 167 (11.2) | 0.318 |
| CCI score, mean (SD) | 0.3 (0.8) | 0.3 (0.9) | 0.3 (0.8) | < 0.001 |
| Crohn disease | 38 (0.7) | 26 (0.8) | 11 (0.7) | 0.917 |
| Ulcerative colitis | 42 (0.8) | 35 (1.0) | 16 (1.1) | 0.301 |
| Peripheral vascular disease | 47 (0.8) | 35 (1.0) | 11 (0.7) | 0.581 |
| Cerebrovascular disease | 124 (2.2) | 93 (2.7) | 23 (1.6) | 0.046 |
| Ischemic heart disease | 203 (3.6) | 151 (4.1) | 64 (4.2) | 0.446 |
| Previous myocardial infarction | 56 (1.0) | 47 (1.4) | 24 (1.6) | 0.093 |
| Cardiac dysrythmia | 208 (3.7) | 138 (4.0) | 39 (2.6) | 0.063 |
| Antidepressant drug use | 709 (12.6) | 444 (12.8) | 200 (13.5) | 0.704 |
| SSRI | 519 (9.3) | 308 (8.9) | 134 (9.1) | 0.810 |
| TCA | 222 (4.0) | 158 (4.5) | 76 (5.1) | 0.107 |
| SNRI | 385 (6.9) | 278 (8.0) | 91 (6.1) | 0.033 |
| Other | 3 (0.1) | 0 (0.0) | < 3* | 0.364 |
| Antipsychotics | 218 (3.9) | 119 (3.4) | 48 (3.2) | 0.340 |
| Anxiolytic drug use | 219 (3.9) | 137 (3.9) | 50 (3.4) | 0.586 |
| Psychologist consultation | 136 (2.4) | 51 (1.5) | 47 (3.2) | < 0.001 |
| Psychiatrist consultation | 86 (1.5) | 44 (1.3) | 26 (1.8) | 0.337 |
| Any psoriasis | 3779 (67.4) | 2303 (66.2) | 1075 (72.3) | < 0.001 |
| Dermatologist-diagnosed psoriasis | 1552 (27.7) | 687 (19.8) | 531 (35.7) | < 0.001 |
| Mild psoriasis | 656 (11.7) | 355 (10.2) | 277 (18.6) | |
| Moderate psoriasis | 578 (10.3) | 236 (6.8) | 140 (9.4) | |
| Severe psoriasis | 318 (5.7) | 96 (2.8) | 114 (7.7) |
Data are n (%) unless otherwise specified.
↵* Data shown as < 3 because of data security requirements. PsA: psoriatic arthritis; CCI: Charlson Comorbidity Index; SSRI: selective serotonin reuptake inhibitors; TCA: tricyclic antidepressants; SNRI: serotonin norepinephrine reuptake inhibitor.