Prevalence of selected comorbidities in RA cases and controls.
| Variables | RA Cases (n = 96,921), % (95% CI) | Controls (n = 484,605), % (95% CI) |
|---|---|---|
| Cardiovascular disorders | ||
| Cardiac arrhythmia | 18.9 (18.7–19.2) | 13.2 (13.1–13.3) |
| Congestive heart failure | 10.3 (10.1–10.4) | 6.0 (6.0–6.1) |
| Coronary heart disease | 15.3 (15.1–15.5) | 9.6 (9.5–9.6) |
| Myocardial infarction | 1.4 (1.3–1.4) | 0.8 (0.8–0.8) |
| Stroke | 2.7 (2.6–2.8) | 1.9 (1.9–2.0) |
| Valvular diseases | 10.9 (10.7–11.1) | 7.1 (7.0–7.2) |
| Vascular diseases | 13.0 (12.8–13.2) | 8.5 (8.5–8.6) |
| Thrombosis | ||
| Arterial thrombosis/embolism | 0.4 (0.4–0.5) | 0.2 (0.2–0.3) |
| Venous thrombosis | 2.9 (2.8–3.0) | 1.5 (1.5–1.6) |
| Pulmonary embolism | 1.1 (1.0–1.1) | 0.5 (0.5–0.5) |
| Cardiovascular risk factors | ||
| Hypertension | 62.5 (62.2–62.8) | 47.9 (47.8–48) |
| Hyperlipidemia | 39.9 (39.6–40.2) | 32.3 (32.2–32.5) |
| Obesity | 18.0 (17.8–18.2) | 12.2 (12.1–12.3) |
| Musculoskeletal diseases | ||
| Osteoarthritis | 44.0 (43.7–44.3) | 21.4 (21.2–21.5) |
| Osteoporosis | 25.9 (25.6–26.2) | 9.4 (9.3–9.5) |
| Neoplasms | ||
| Lymphoma | 1.0 (1–1.1) | 0.6 (0.6–0.6) |
| Metastatic cancer | 1.7 (1.7–1.8) | 1.4 (1.4–1.5) |
| Solid tumor without metastasis | 13.9 (13.6–14.1) | 11.4 (11.4–11.5) |
| Pulmonary diseases | ||
| Asthma | 12.5 (12.2–12.7) | 7.3 (7.2–7.3) |
| Chronic obstructive pulmonary disease | 11.3 (11.1–11.5) | 6.5 (6.4–6.5) |
| Other diseases | ||
| Depression | 31.8 (31.5–32.1) | 20.1 (20.0–20.3) |
| Diabetes | 21.7 (21.4–21.9) | 15.2 (15.1–15.3) |
| Hypothyroidism | 18.1 (17.9–18.4) | 12.8 (12.7–12.9) |
| Inflammatory bowel disease | 2.3 (2.2–2.4) | 0.8 (0.8–0.9) |
| Liver disease | 13.9 (13.7–14.2) | 9.0 (8.9–9.0) |
| Renal failure | 10.2 (10.0–10.4) | 5.4 (5.4–5.5) |
RA: rheumatoid arthritis.