Table 3.

Univariate analysis of variables associated with hepatotoxicity.

VariablesHR95% CIp
Age, yrs0.9700.945–0.9960.024
Female0.0480.343–7.2300.595
BMI, > 30 kg/m2*0.7580.331–1.7370.513
Diabetes mellitus1.8610.779–4.4490.162
Hypertension0.6690.366–1.3360.279
Renal insufficiency1.0950.389–3.0850.864
Colchicine9.3304.695–18.541< 0.001
Statin0.5440.265–1.1160.097
Alcohol intake0.494
  None, ref
  < 50 g/week0.8580.413–1.7790.680
  > 50 g/week1.7580.480–6.4390.394
FLD severity0.891
  Mild, ref
  Moderate1.1010.554–2.1870.783
  Severe0.8820.344–2.2600.794
Allopurinol, ref
  Febuxostat0.2470.076–0.8020.020
NSAID1.5660.686–3.5750.287
  • * Missing value was excluded from analysis. BMI: body mass index; FLD: fatty liver disease; NSAID: nonsteroidal antiinflammatory drugs.