Characteristics of adults who develop accelerated HOA. Values are n (%) unless otherwise specified.
| Variables | No Accelerated HOA, n = 3481 | Accelerated HOA, n = 38 | Difference Between Groups (95% CI) |
|---|---|---|---|
| Baseline characteristics* | |||
| Female | 1993 (57) | 28 (74) | 16 (2–31)a |
| Premenopause | 298 (15) | 2 (7) | −8 (−18 to 2) |
| Perimenopause | 274 (14) | 2 (7) | −7 (−16 to 3) |
| Postmenopause | 1411 (71) | 24 (86) | 15 (1–28) |
| Metabolic syndrome, 2–4 components | 1914 (57) | 23 (61) | 3 (−13 to 19)a |
| Self-reported diabetes | 235 (7) | 1 (3) | −4 (−9 to 1) |
| Use of lipid medications | 983 (28) | 11 (29) | 1 (−14 to 15) |
| High blood pressure | 2079 (59) | 24 (63) | 4 (−12 to 19) |
| Large waist circumference | 2540 (75) | 29 (76) | 2 (−12 to 15)a |
| Physician-diagnosed HOA | 534 (15) | 16 (42) | 27 (11–43) |
| Prevalent hand pain | 756 (22) | 14 (37) | 15 (0–31) |
| Age, yrs, mean (SD) | 61.0 (9.1) | 64.9 (8.3) | 3.9 (1.0–6.8) |
| Body mass index, kg/m2, mean (SD) | 28.5 (4.8) | 27.4 (4.5) | −1.1 (−2.7 to 0.4) |
| Body weight, kg, mean (SD) | 81.2 (16.2) | 74.3 (14.5) | −6.9 (−12.1 to −1.7) |
| Baseline radiographic hand characteristics* | |||
| Radiographic HOA | 1236 (35) | 27 (71) | 36 (21–50) |
| Central erosions, ≥ 1 joint | 233 (7) | 8 (22) | 15 (2–28) |
| Marginal erosions, ≥ 1 joint | 81 (2) | 4 (11) | 8 (−2 to 18)a |
| No. joints with KL ≥ 3, mean (SD) | 0.5 (1.2) | 1.1 (2.0) | 0.6 (−0.02 to 1.3) |
| Incident findings over time | |||
| Incident accelerated knee OA | 105 (3) | 3 (8) | 5 (−4 to 13) |
| New central erosions over 48 mos | 158 (5) | 13 (35) | 31 (15–46)a |
| New marginal erosions over 48 mos | 50 (1) | 2 (5) | 4 (−3 to 11) |
↵* Collected at baseline.
↵a Discordance in group difference is related to rounding. Notes on missing data: Only included people with body weight, and status of self-reported hand pain (yes or no), and physician-diagnosed HOA (yes and no or unknown) at baseline. Missing data: Less than 3% missing data for menopause status, central erosions, marginal erosions, diabetes status, and waist circumference. Metabolic syndrome (n missing = 137 controls). No other missing data. HOA: hand osteoarthritis; KL: Kellgren-Lawrence arthritis grading scale.