HCQ levels throughout pregnancy.
| Trimester | Total Daily Dose, mg | n (samples) | HCQ Level, ng/ml | ||
|---|---|---|---|---|---|
| Mean (SD) | Range | Median (IQR) | |||
| 1st | 200 | 2 | 158 (116) | 76–240 | 158 (76–240) |
| 300 | 5 | 219 (131.6) | < 10–350 | 250 (200–290) | |
| 400 | 17 | 440.6 (281.3) | < 10–1000 | 430 (260–500) | |
| Overall | 24 | 370.9 (266.8) | < 10–1000 | 320 (220–485) | |
| 2nd | 200 | 2 | 290 (113.1) | 210–370 | 290 (210–370) |
| 300 | 5 | 350 (160.3) | 190–520 | 300 (220–520) | |
| 400 | 53 | 373.7 (238.6) | < 10–1100 | 370 (220–500) | |
| Overall | 60 | 369 (228.9) | < 10–1100 | 365 (215–505) | |
| 3rd | 300 | 3 | 160 (120) | 40–280 | 160 (40–280) |
| 400 | 31 | 319 (194.6) | < 10–900 | 310 (230–380) | |
| Overall | 34 | 304.9 (193.4) | < 10–900 | 300 (230–370) | |
| Postpartum | 400 | 26 | 438.1 (255) | < 10–1100 | 385 (310–600) |
| 457* | 1 | 48 | 48 | 48 | |
| Overall | 27 | 423.6 (261.1) | < 10–1100 | 360 (310–600) | |
↵* Participant reported taking 400 mg 5 days/week and 600 mg 2 days/week. HCQ: hydroxychloroquine; IQR: interquartile range.