Comparison between BNP/cTnI abnormal and BNP/cTnI normal patients.
| Variables | BNP/cTnI Abnormal, n = 16 | BNP/cTnI Normal, n = 135 | p |
|---|---|---|---|
| Age, yrs, mean ± SD | 54.7 ± 15.1 | 47.1 ± 12.4 | 0.025 |
| Female | 14 (87.5) | 125 (92.6) | 0.476 |
| Male | 2 (12.5) | 10 (7.4) | |
| Ethnicity | |||
| White | 10 (62.5) | 70 (51.9) | 0.393 |
| Black | 3 (18.8) | 27 (20) | |
| Asian | 3 (18.8) | 18 (13.3) | |
| Other | 0 | 20 (14.8) | |
| SLE duration, yrs, mean ± SD | 22.54 ± 10.44 | 14.83 ± 9.73 | 0.003 |
| SLEDAI-2K, mean ± SD | 1.88 ± 2.47 | 2.92 ± 3.71 | 0.276 |
| eGFR, ml/min, mean ± SD | 82.7 ± 21.58 | 117.3 ± 116.4 | 0.003 |
| eGFR < 30 ml/min | 0 (0) | 3 (2.2) | 0.547 |
| Hypothyroidism | 2 (12.5) | 5 (3.7) | 0.114 |
| Hypertension | 10 (62.5) | 45 (33.3) | 0.022 |
| Diuretics treatment | 5 (31.3) | 7 (5.2) | < 0.001 |
| Mean systolic BP, mmHg, mean ± SD§ | 119.58 ± 17.1 | 113.3 ± 12.9 | 0.078 |
| Mean diastolic BP, mmHg, mean ± SD§ | 72 ± 7.6 | 70.4 ± 8.5 | 0.486 |
| Systolic BP at test, mmHg, mean ± SD | 118.4 ± 21.7 | 113.2 ± 16.8 | 0.258 |
| Diastolic BP at test, mmHg | 71.9 ± 10.1 | 69.4 ± 12.1 | 0.43 |
| Diabetes | 0 (0) | 7 (5.2) | 0.351 |
| Dyslipidemia | 4 (25) | 30 (20.7) | 0.693 |
| Abnormal CPK* | 7 (43.8) | 22 (16.3) | 0.008 |
| Ever on AM | 16 (100) | 126 (93.3) | 0.287 |
| Ever on CQ | 5 (31.3) | 23 (17) | 0.167 |
| Ever on HCQ | 14 (87.5) | 123 (91.1) | 0.638 |
| Cumulative dose of CQ, g, mean ± SD | 1509 ± 690 | 900 ± 287 | 0.003 |
| Cumulative dose of HCQ, g, mean ± SD | 1251 ± 883 | 1057 ± 695 | 0.335 |
| Yrs taking AM, cumulative, mean ± SD | 13.66 ± 9.14 | 7.27 ± 7.51 | 0.002 |
| Taking AM > 5.6 yrs | 14 (87.5) | 57 (42.2) | < 0.001 |
| Corticosteroids | 8 (50) | 64 (47.4) | 0.844 |
| Mean prednisone, mg/day, mean ± SD | 9.4 ± 4.2 | 7.6 ± 5.3 | 0.374 |
| Immunosuppressives | 10 (62.5) | 79 (58.5) | 0.76 |
Data are n (%) unless otherwise indicated. Significant data are in bold face.
↵§ Mean value of last 4 visits.
↵* Three abnormal measurements during the last 2 years. eGFR: estimated glomerular filtration rate; BP: blood pressure; CPK: creatine phosphokinase; AM: antimalarials; CQ: chloroquine; HCQ: hydroxychloroquine; BNP: brain natriuretic peptide; cTnI: cardiac troponin I; SLE: systemic lupus erythematosus; SLEDAI-2K: SLE Disease Activity Index 2000.