The predictive power of combination of various aPL in the diagnosis of APS. Except for likelihood ratios (LR), data are percentages.
| Sensitivity | Specificity | PPV | NPV | LR+ | LR– | |
|---|---|---|---|---|---|---|
| aPT/PS IgG or IgM or LAC | 79.70 | 79.50 | 85.30 | 72.30 | 3.89 | 0.26 |
| aPT/PS IgG or IgM or aCL IgG or IgM | 78.80 | 77.00 | 83.70 | 70.90 | 3.43 | 0.27 |
| aPT/PS IgG or IgM or anti-β2-GPI IgG or IgM | 73.40 | 79.50 | 84.30 | 66.70 | 3.58 | 0.33 |
| LAC or aCL IgG or IgM or anti-β2-GPI IgG or IgM | 84.20 | 84.50 | 89.00 | 78.20 | 5.42 | 0.19 |
| LAC or aCL IgG or IgM or anti-β2-GPI IgG or IgM or aPT/PS IgG or IgM | 87.10 | 71.40 | 82.00 | 78.80 | 3.05 | 0.18 |
| aPT/PS IgG or IgM and LAC | 52.70 | 99.40 | 99.20 | 58.40 | 84.84 | 0.48 |
| aPT/PS IgG or IgM and aCL IgG or IgM | 46.90 | 98.10 | 97.40 | 55.20 | 25.16 | 0.54 |
| aPT/PS IgG or IgM and anti-β2-GPI IgG or IgM | 29.90 | 98.80 | 97.30 | 48.50 | 24.05 | 0.71 |
| aCL IgG or IgM and LAC | 46.90 | 99.40 | 99.10 | 55.60 | 75.49 | 0.53 |
| anti-β2-GPI IgG or IgM and LAC | 30.70 | 98.80 | 97.40 | 48.80 | 24.72 | 0.70 |
| LAC and aCL IgG or IgM and aPT/PS IgG or IgM | 38.60 | 100.00 | 100.00 | 52.10 | NA | 0.61 |
| LAC and aCL IgG or IgM and anti-β2-GPI IgG or IgM | 29.50 | 99.40 | 98.60 | 48.50 | 47.43 | 0.71 |
| LAC and aCL IgG or IgM and anti-β2-GPI IgG or IgM and aPT/PS IgG or IgM | 23.20 | 100.00 | 100.00 | 46.50 | NA | 0.77 |
aPL: antiphospholipid antibodies; APS: antiphospholipid syndrome; PPV: positive predictive value; NPV: negative predictive value; NA: not applicable; aPT/PS: antiphosphatidylserine/prothrombin antibodies; aCL: anticardiolipin antibodies; anti-β2-GPI: anti-β2-glycoprotein I; LAC: lupus anticoagulants.