Demographic and clinical characteristics of scleroderma renal crisis (SRC) cases and systemic sclerosis (SSc) without SRC disease controls. Data are %, n/N unless otherwise specified.
| Characteristics | SRC, n = 31 | SSc without SRC, n = 322 | p |
|---|---|---|---|
| Race | |||
| White | 48, 15/31 | 57, 158/279 | NS |
| Black | 42, 13/31 | 24, 66/279 | 0.03 |
| Other | 10, 3/31 | 20, 63/279 | NS |
| Sex, % female | 74, 23/31 | 84, 271/322 | NS |
| Age, yrs, median (IQR) | 53 (40–60) | 46 (37–54) | 0.01 |
| Time between SSc and SRC, yrs, median (IQR) | 3 (1–5) | NA | NA |
| SSc followup, yrs, median (IQR) | 6 (3–8) | 5 (2–8) | NS |
| Pulmonary fibrosis | 42, 13/31 | 31, 100/322 | NS |
| Pulmonary HTN | 39, 12/31 | 12, 40/322 | < 0.001 |
| Cardiac involvement | 23, 7/31 | 5, 17/322 | 0.002 |
| GI involvement | 77, 24/31 | 82, 265/322 | NS |
| RP | 90, 28/31 | 97, 313/322 | NS |
| Digital ulcers | 29, 9/31 | 23, 73/322 | NS |
| Prior prednisone | 65, 20/31 | 19, 62/322 | < 0.001 |
| Other IST | 32, 10/31 | 32, 104/322 | NS |
| Diffuse SSc | 39, 12/31 | 16, 52/322 | 0.004 |
| Limited SSc | 61, 19/31 | 74, 237/322 | NS |
| Sine SSc | 0, 0/31 | 1, 4/322 | NS |
| Unknown | 0, 0/31 | 9, 29/322 | NS |
IQR: interquartile range; HTN: hypertension; GI: gastrointestinal; RP: Raynaud phenomenon; IST: immunosuppression therapy; NS: not significant; NA: not applicable; sine SSc: SSc sine scleroderma.