Variables | Time 1 | Time 2 | p |
---|---|---|---|
Disease duration at time of HRCT, yrs | 8.8 (0.6–33.6) | 17.8 (3.1–40.2) | NA |
Disease duration at time of PFT, yrs | 11.6 (3.3–30.9) | 17.7 (2.3–41.2) | NA |
Age at PFT examination, yrs | 21.9 (6.5) | 32.2 (6.7) | NA |
Age at HRCT, yrs | 21.7 (7.3) | 29.3 (8.6) | NA |
Time between HRCT scans | 8.3 (2.7) | NA | |
Time between PFT | 10.3 (1.0) | NA | |
FVC% | 92.7 (11.4) | 85.6 (15.6) | 0.004 |
FEV1% | 94.6 (12.0) | 85.9 (10.3) | 0.001 |
FEV1/FVC ratio | 0.87 (0.05) | 0.84 (0.05) | NS |
DLCO% | 72.2 (14.0) | 70.5 (11.3) | NS |
DLCO/VA% | 88.2 (15.7) | 88.2 (15.1) | NS |
ILD present, n (%) | 9 (24) | 10 (27) | NS |
Ground-glass attenuation, n (%) | 3 (8) | 0 | NS |
Reticular pattern, n (%) | 7 (19) | 10 (27) | NS |
Grade 1 | 8 (22) | 9 (24) | NS |
Grade 2 | 4 (11) | 6 (16) | NS |
Grade 3 | 0 | 1 (3) | NS |
Lung parenchyma with ILD, % | 2.0 (1–18) | 4.0 (1–18) | NS |
HRCT: high-resolution computed tomography; PFT: pulmonary function tests; JMCTD: juvenile mixed connective tissue disease; ILD: interstitial lung disease; FVC: forced vital capacity; FEV1: forced expiratory volume in 1 s; DLCO: diffusion capacity of carbon monoxide; VA: alveolar volume; NA: not assessed; NS: not significant.