HCQ, ≤ 100 ng/ml | HCQ, 101–500 ng/ml | HCQ, > 500 ng/ml | p** | p*** | |
---|---|---|---|---|---|
All patients | n = 7 | n = 32 | n = 7 | ||
GA, weeks | 36 (30–37) | 39 (38–39) | 36 (29–37) | < 0.01 | < 0.0001 |
Preterm birth | 5 (71) | 2 (6) | 4 (57) | < 0.01 | < 0.0001 |
Birth weight, g | 2451 (1530–2580) | 3118 (2835–3629) | 2175 (915–2750) | 0.07 | 0.003 |
SLE patients | n = 6 | n = 14 | n = 5 | ||
GA, weeks | 35.5 (30–36) | 38.5 (38–39) | 35 (29–36) | 0.03 | 0.0003 |
Preterm birth | 5 (83) | 0 (0) | 4 (80) | 0.01 | < 0.0001 |
Birth weight, g | 2347 (1530–2555) | 3147 (2665–3685) | 1885 (915–2505) | 0.3 | 0.02 |
Non-SLE patients | n = 1 | n = 18 | n = 2 | ||
GA, weeks | 37 | 39 (37–39) | 37.5 (37–38) | 0.4 | 0.4 |
Preterm birth | 0 (0) | 2 (11) | 0 (0) | 1 | 1 |
Birth weight, g | 2580 | 3118 (2977–3345) | 2877.5 (2175–3580) | 0.2 | 0.4 |
Categorical variables listed as n (%); continuous variables listed as median (IQR).
↵* N = 46; 2 pregnancies ended in nonlive births and 2 pregnancies had unknown neonatal outcomes.
↵** Comparing ≤ 100 ng/ml vs > 100 ng/ml.
↵*** Comparing ≤ 100 ng/ml vs 101–500 ng/ml vs > 500 ng/l. Values in bold face are statistically significant. HCQ: hydroxychloroquine; GA: gestational age at birth; SLE: systemic lupus erythematosus; IQR: interquartile range.