Multivariable linear regression models for association of preconceptional CV health and pregnancy outcomes in SLE in the Hopkins Lupus Pregnancy Cohort (n = 309 pregnancies).
| CV Health | Gestational Age | Birth Weight for Gestational Age Z Score | ||
|---|---|---|---|---|
| β (95% CI) | Adjusted β (95% CI) | β (95% CI) | Adjusted β (95% CI) | |
| BMI* | ||||
| Ideal health (low/normal BMI), n = 163 | Ref | Ref | Ref | Ref |
| Intermediate health (overweight), n = 69 | 0.19 (−0.65 to 1.01) | 0.14 (−0.63 to 0.93)§ | 0.29 (0.03–0.56) | 0.32 (0.06–0.59)§ |
| Poor health (obese), n = 59 | 0.75 (−0.21 to 1.71) | 0.70 (−0.24 to 1.65)§ | 0.08 (−0.24 to 0.41) | 0.14 (−0.18 to 0.45)§ |
| Total cholesterol † | ||||
| Ideal health, n = 235 | Ref | Ref | Ref | Ref |
| Intermediate/poor health, n = 40 | −0.53 (−1.46 to 0.40) | −0.43 (−1.28 to 0.41)§ | 0.02 (−0.29 to 0.33) | 0.03 (−0.28 to 0.34)§ |
| −0.39 (−1.30 to 0.51) ‖ | −0.02 (−0.32 to 0.29) ‖ | |||
| −0.37 (−1.22 to 0.48)¶ | −0.02 (−0.33 to 0.30)¶ | |||
| BP ‡ | ||||
| Ideal health, n = 158 | Ref | Ref | Ref | Ref |
| Intermediate/poor health, n = 151 | −1.14 (−1.83 to −0.45) | −0.96 (−1.62 to −0.29) # | 0.02 (−0.19−0.24) | 0.09 (−0.12 to 0.31) # |
| Continuous variables | ||||
| BMI, kg/m2 (n = 291) | 0.05 (−0.004 to 0.11) | 0.06 (0.001–0.11)§ | 0.01 (−0.01 to 0.03) | 0.02 (−0.01 to 0.04)§ |
| Total cholesterol, 10 mg/dl (n = 275) | −0.07 (−0.18 to 0.04) | −0.06 (−0.15 to 0.04)§ | 0.01 (−0.02 to 0.03) | 0.01 (−0.02 to 0.04)§ |
| −0.06 (−0.16 to 0.04) ‖ | 0.004 (−0.02 to 0.03) ‖ | |||
| −0.05 (−0.14 to 0.04)¶ | 0.005 (−0.02 to 0.03)¶ | |||
| Systolic BP, 10 mmHg (n = 309) | −0.46 (−0.71 to −0.21) | −0.39 (−0.63 to −0.15) # | 0.004 (−0.06 to 0.07) | 0.03 (−0.04 to 0.10) # |
| Diastolic BP, 10 mmHg (n = 309) | −0.60 (−0.98 to −0.22) | −0.52 (−0.89 to −0.14) # | 0.01 (−0.09 to 0.11) | 0.04 (−0.06 to 0.15) # |
↵* BMI: poor health ≥ 30 kg/m2; intermediate health 25–29.9 kg/m2; ideal health < 25 kg/m2.
↵† Total cholesterol: poor health ≥ 240 mg/dl; intermediate health 200–239 mg/dl or treated to goal; ideal health < 200 mg/dl.
↵‡ BP: poor health (systolic ≥ 140 or diastolic ≥ 90 mmHg); intermediate health (systolic 120–139 or diastolic 80–89 mmHg or treated to goal); ideal health < 120/< 80 mmHg.
↵§ Adjusted for race (black vs nonblack) and prednisone use ever during pregnancy.
↵‖ Adjusted for race (black vs nonblack) and antimalarial use ever during pregnancy.
↵¶ Adjusted for race (black vs nonblack), prednisone use ever during pregnancy, and antimalarial use ever during pregnancy.
↵# Adjusted for race (black vs nonblack) and renal involvement during pregnancy (Renal LAI ≥ 1). SLE: systemic lupus erythematosus; BMI: body mass index; LAI: Lupus Activity Index; BP: blood pressure; CV: cardiovascular.