Comparison of disease manifestations between SSc-SLE and SSc subjects.
| Disease Manifestations | SSc, n (%) | SSc-SLE overlap, n (%) | SMD*, % |
|---|---|---|---|
| Calcinosis | 310 (27) | 11 (13) | 35 |
| Raynaud phenomenon | 1110 (95) | 80 (93) | 9 |
| Esophageal dysmotility | 1005 (86) | 67 (78) | 22 |
| Sclerodactyly | 1095 (94) | 57 (66) | 74 |
| Telangiectasia | 877 (75) | 42 (49) | 56 |
| Interstitial lung disease | 396 (34) | 35 (41) | 14 |
| Pulmonary arterial hypertension | 362 (31) | 45 (52) | 44 |
| Scleroderma renal crisis | 76 (7) | 6 (7) | 2 |
| Abnormal nailfold capillaries | 370 (32) | 27 (31) | 0.7 |
| Digital ulcers | 378 (32) | 33 (38) | 12 |
| Scl-70 antibody | 202 (17) | 10 (12) | 16 |
| Centromere antibody | 229 (20) | 12 (14) | 15 |
| Lupus anticoagulant | 4 (0.3) | 5 (6) | 32 |
| Anticardiolipin antibody | 11 (0.9) | 5 (6) | 27 |
↵* SMD > 25% is considered a meaningful difference between groups. SSc: systemic sclerosis; SLE: systemic lupus erythematosus; SMD: standardized mean difference.