Table 2.

Risk of composite CVD outcome* in ABA initiators versus TNFi: 1:1 PS matched analysis.

DatabaseExposureTotal NNo. EventIR, per 100 PYHR (95% CI)Combined HR (95% CI)
Overall
MedicareABA61021852.380.67 (0.55–0.81)0.79 (0.67–0.92)
TNFi61022483.58Ref
MarketScanABA69341141.381.08 (0.83–1.41)
TNFi69341131.27Ref
With baseline CVD
MedicareABA21561074.180.71 (0.55–0.92)0.79 (0.64–0.98)
TNFi21561345.92Ref
MarketScanABA968494.601.02 (0.68–1.51)
TNFi968494.35Ref
Without baseline CVD
MedicareABA3946781.500.61 (0.46–0.82)1.04 (0.74–1.46)
TNFi39461142.44Ref
MarketScanABA5966650.911.10 (0.77–1.57)
TNFi5966640.82Ref
  • * Composite CVD is any of MI, stroke/TIA or coronary revascularization. CVD: cardiovascular disease; ABA: abatacept; TNFi: tumor necrosis factor inhibitors; PS: propensity score; IR: incidence rate; MI: myocardial infarction; PY: person-years; TIA: transient ischemic attack.