Database | Exposure | Total N | No. Event | IR, per 100 PY | HR (95% CI) | Combined HR (95% CI) |
---|---|---|---|---|---|---|
Overall | ||||||
Medicare | ABA | 6102 | 185 | 2.38 | 0.67 (0.55–0.81) | 0.79 (0.67–0.92) |
TNFi | 6102 | 248 | 3.58 | Ref | ||
MarketScan | ABA | 6934 | 114 | 1.38 | 1.08 (0.83–1.41) | |
TNFi | 6934 | 113 | 1.27 | Ref | ||
With baseline CVD | ||||||
Medicare | ABA | 2156 | 107 | 4.18 | 0.71 (0.55–0.92) | 0.79 (0.64–0.98) |
TNFi | 2156 | 134 | 5.92 | Ref | ||
MarketScan | ABA | 968 | 49 | 4.60 | 1.02 (0.68–1.51) | |
TNFi | 968 | 49 | 4.35 | Ref | ||
Without baseline CVD | ||||||
Medicare | ABA | 3946 | 78 | 1.50 | 0.61 (0.46–0.82) | 1.04 (0.74–1.46) |
TNFi | 3946 | 114 | 2.44 | Ref | ||
MarketScan | ABA | 5966 | 65 | 0.91 | 1.10 (0.77–1.57) | |
TNFi | 5966 | 64 | 0.82 | Ref |
↵* Composite CVD is any of MI, stroke/TIA or coronary revascularization. CVD: cardiovascular disease; ABA: abatacept; TNFi: tumor necrosis factor inhibitors; PS: propensity score; IR: incidence rate; MI: myocardial infarction; PY: person-years; TIA: transient ischemic attack.