Table 2.

Cochrane Risk of Bias assessment.

Study, Yr	Random Sequence Generation		Allocation Concealment		Blinding of Participants and Personnel		Blinding of Outcome Assessment		Incomplete Outcome Data		Selective Reporting		Other Sources of Bias
Kavanaugh, et al, 2006¹⁰	Stratified randomization with algorithm	^*	Computer-generated	^*	Administered by blinded investigators	^*	Patients unaware of whether they received drug or PBO	^*	No. patients for productivity assessment not provided	^**	None identified	^*	None identified	^*
Kavanaugh, et al, 2009¹¹	Centralized interactive voice-Web response system	^*	Interactive voice response system	^*	PBO and drug not distinguished	^*	Assessed by independent assessors with no record access	^*	No. employed participants not provided	^**	None identified	^*	None identified	^*
Kavanaugh, et al, 2012¹²	Centralized interactive voice-Web response system	^*	Interactive voice response system	^*	Participant and physicians blinded to intervention and dosage	^*	Not described	^**	No. employed participants not provided	^**	None identified	^*	None identified	^*
Kavanaugh, et al, 2015¹³	Stratified randomization with interactive voice response system	^*	Interactive voice response system	^*	Dose-blinded participants and personnel with blinded prefilled syringes	^*	Not described	^**	Biologic-naive not separated from biologic-experienced	^**	None identified	^*	None identified	^*
Zhang, et al, 2014¹⁴	Not described	^**	Not described	^**	Not described	^**	Blinded investigators	^*	No. employed participants not provided	^**	None identified	^**	None identified	^*