Median time to loss of remission in remission phases with and without US-detected residual synovitis.
| Variables | n/Nx | US+, Median Duration, yrs | 95% CI | US−, Median Duration, yrs | 95% CI | Log-rank p |
|---|---|---|---|---|---|---|
| Overall cohort | ||||||
| Combined score | 321/188 | 2.1 | 1.5–2.4 | 2.5 | 2.1–3.7 | 0.03 |
| Doppler only | 341/203 | 2.1 | 1.4–2.4 | 2.4 | 2–2.8 | 0.13 |
| B-mode total (> 8/66) | 378/226 | 2 | 1.2–2.3 | 2.2 | 2–2.7 | 0.14 |
| B-mode (≥ 2 joints with synovitis grade ≥ 2) | 378/226 | 2 | 1.1–2.4 | 2.2 | 2–2.5 | 0.14 |
| Early US subset | ||||||
| Left imputation | ||||||
| Combined score | 94/64 | 0.8 | 0.7–2 | 2.4 | 1–NE | 0.008 |
| Doppler only | 99/66 | 0.8 | 0.5–2 | 2.0 | 1–NE | 0.008 |
| B-mode total (> 8/66) | 116/81 | 0.8 | 0.6–2.0 | 1.3 | 0.8–2.1 | 0.36 |
| B-mode (≥ 2 joints with synovitis grade ≥ 2) | 116/81 | 0.7 | 0.4–1.6 | 1.4 | 0.9–2.2 | 0.029 |
| Right imputation | ||||||
| Combined score | 247/154 | 1.7 | 1.1–2.2 | 2.4 | 2–3.7 | 0.019 |
| Doppler only | 263/166 | 1.5 | 1–2.1 | 2.2 | 1.5–2.8 | 0.027 |
| B-mode total (> 8/66) | 293/183 | 1.5 | 1–2.2 | 2.1 | 1.5–2.5 | 0.13 |
| B-mode (≥ 2 joints with synovitis grade ≥ 2) | 293/183 | 1.5 | 1–2.2 | 2.1 | 1.5–2.4 | 0.069 |
Data in boldface are statistically significant. US: ultrasound; US±: with or without US-detected residual synovitis; n: no. remission phases; Nx: no. loss of remission; NE: not estimable.