Sensitivity, specificity, and likelihood ratios for the determined cutoff of S100A12 predicting response to MTX and anti-TNF therapy.
| Accuracy Measure | MTX Therapy | Anti-TNF Therapy |
|---|---|---|
| Cutoff level S100A12, ng/ml | 260 | 213 |
| Sensitivity | 47.4 | 58.6 |
| Specificity | 88.9 | 80.7 |
| Positive likelihood ratio | 4.3 | 3.0 |
| Negative likelihood ratio | 1.7 | 0.5 |
| Youden index | 0.363 | 0.392 |
| AUC (95% CI) | 0.675 (0.559–0.805) | 0.734 (0.622–0.846) |
AUC: area under the curve; MTX: methotrexate; anti-TNF: antitumor necrosis factor.