Table 1.

Clinical characteristics of patients with GPA and MPA with and without GI disease. Mann-Whitney U test was used for continuous variables and chi-square test for frequencies.

CharacteristicsWithout GI Disease, n = 202With GI Disease, n = 14p
Men/women (%)108/94 (53/47)9/5 (64/36)0.43
Age*, yrs, median (quartiles)63.4 (53.3–73.0)65.7 (50.3–77.5)0.55
Tertiary referral patients, n (%)39 (19)3 (21)0.86
GPA/MPA, n (%)120/82 (59/41)10/4 (71/29)0.37
PR3–/MPO–/no or missing ANCA/both, n (%)120/70/7/5 (59/35/3.5/2.5)10/4/0/0 (71/29/0/0)0.86
Organ involvement*, n (%)
  Kidney137 (68)11 (79)0.40
  Lung73 (36)8 (57)0.12
  ENT84 (42)5 (36)0.67
  Peripheral nerves51 (25)4 (29)0.78
  Skin22 (11)3 (21)0.23
  Joints, eyes78 (39), 19 (9)6 (43), 1 (7)0.75, 0.78
Isolated ENT disease, n (%)16 (8)0.27
Plasma creatinine*, μmol/l, median (quartiles)123 (80–272)125 (88–216)0.89
Plasma CRP*, mg/l, median (quartiles)81 (18–142)98 (82–170)0.16
BVAS* median (quartiles)15 (12–20)22 (15–28)0.001
  • * At time of diagnosis. GI: gastrointestinal; GPA: granulomatosis with polyangiitis; MPA: microscopic polyangiitis; PR3: proteinase 3; MPO: myeloperoxidase; CRP: C-reactive protein; BVAS: Birmingham Vasculitis Activity Score.