Characteristics | Concurrent, n = 102 | Biologic Alone, n = 206 | ||
---|---|---|---|---|
Missing Data, n (%) | Missing Data, n (%) | |||
Women, n (%) | 90 (88.2) | 0 (0) | 158 (76.7) | 0 (0) |
Age, yrs | 66.4 (10.6) | 0 (0) | 57.3 (11.7) | 2 (1.0) |
Followup time from index date, yrs | 2.4 (1.2) | 0 (0) | 2.5 (1.3) | 0 (0) |
Duration on denosumab, yrs | 2.4 (1.2) | 0 (0) | NA | NA |
Body mass index, kg/m2 | 27.3 (5.5) | 2 (2.0) | 31.2 (6.3) | 38 (18.4) |
BMD T score ≤ −2.5 at the spine or hip, n (%) | 45 (46.9) | 6 (5.9) | 23 (13.4) | 34 (16.5) |
History of fracture, n (%) | 8 (8.3) | 6 (5.9) | 4 (2.5) | 44 (21.4) |
Cardiovascular disease, n (%) | 7 (6.9) | 0 (0) | 19 (9.2) | 0 (0) |
Chronic kidney disease, n (%) | 1 (1.0) | 0 (0) | 4 (1.9) | 0 (0) |
Chronic obstructive pulmonary disease, n (%) | 4 (3.9) | 0 (0) | 16 (7.8) | 0 (0) |
Diabetes, n (%) | 8 (7.8) | 0 (0) | 25 (12.1) | 0 (0) |
Liver disease, n (%) | 1 (1.0) | 0 (0) | 1 (0.5) | 0 (0) |
Smoking status, n (%) | 1 | 13 | ||
Past | 25 (24.8) | NA | 52 (26.9) | NA |
Current | 12 (11.9) | NA | 37 (19.2) | NA |
Never | 64 (63.4) | NA | 104 (53.9) | NA |
Baseline rheumatoid arthritis disease activity | ||||
C-reactive protein, mg/l | 4.6 (6.8) | 23 (22.5) | 4.5 (8.0) | 38 (18.4) |
ESR, mm/h | 19.0 (17.0) | 24 (24.5) | 17.2 (15.2) | 38 (18.4) |
Swollen joint count | 4.7 (4.2) | 37 (36.3) | 4.8 (5.0) | 38 (18.4) |
Tender joint count | 8.2 (10.1) | 44 (43.1) | 6.6 (7.0) | 45 (21.8) |
Summary statistics and percentages are calculated based on non-missing observations. Percentages for missing data are calculated based on total population for each group (n = 102, concurrent group; n = 206, biologic-alone group). BMD: bone mineral density; NA: not applicable; ESR: erythrocyte sedimentation rate.