Incidence rates of GC-related AE.
| GC-induced AE | Followup, Yrs, mean (SD) | Events, n | Incidence rate/1000 person-yrs |
|---|---|---|---|
| Musculoskeletal disorders | |||
| Osteoporosis | 5.56 (3.61) | 1769 | 28.17 |
| Osteonecrosis | 6.11 (3.59) | 444 | 6.44 |
| Fractures | 5.77 (3.60) | 1548 | 23.77 |
| Myopathy | 6.25 (3.59) | 79 | 1.12 |
| Gastrointestinal disorders | |||
| Peptic ulcer | 3.75 (3.32) | 6251 | 147.84 |
| Viral hepatitis | 6.18 (3.61) | 305 | 4.37 |
| Pancreatitis | 6.22 (3.59) | 209 | 2.98 |
| Nausea and vomiting | 5.80 (3.60) | 1517 | 23.18 |
| Fatty liver | 6.21 (3.59) | 216 | 3.08 |
| Ophthalmologic disorders | |||
| Cataract | 5.69 (3.60) | 1679 | 26.16 |
| Glaucoma | 6.13 (3.61) | 431 | 6.23 |
| Infectious diseases | |||
| Tuberculosis | 6.09 (3.61) | 540 | 7.85 |
| Fungal infection | 5.38 (3.63) | 2568 | 42.26 |
| Bacterial infection | 3.56 (3.81) | 5489 | 136.42 |
| Cardiovascular disorders | |||
| Dyslipidemia | 5.62 (3.61) | 1709 | 26.94 |
| Atherosclerosis | 6.11 (3.59) | 524 | 7.60 |
| Ischemic heart disease | 6.06 (3.59) | 665 | 9.72 |
| Heart failure | 6.08 (3.60) | 701 | 10.21 |
| Hypertension | 5.41 (3.64) | 2301 | 37.67 |
| Neuropsychiatric disorders | |||
| Psychosis | 6.24 (3.60) | 120 | 1.70 |
| Depression | 5.89 (3.61) | 1002 | 15.07 |
| Cerebrovascular | 5.99 (3.60) | 940 | 13.90 |
| Insomnia | 4.23 (3.57) | 4019 | 78.64 |
| Metabolic/endocrine disorders | |||
| Obesity | 6.26 (3.59) | 80 | 1.13 |
| Gout and hyperuricemia | 5.55 (3.62) | 1868 | 29.81 |
| Cushingoid syndrome | 6.22 (3.59) | 184 | 2.62 |
| Acne vulgaris | 5.67 (3.65) | 1447 | 22.62 |
GC: glucocorticoid; AE: adverse event.