Agreement (concordance) and validity of investigations.
| Variable tested | mPAP ≥ 25 mmHg | mPAP ≥ 25 mmHg | mPAP, ≥ 21 mmHg | ILD | LVD |
|---|---|---|---|---|---|
| Reference investigation | RHC | RHC | RHC | Chest CT scan | TTE |
| No. subjects | 10 | 10 | 10 | 27 | 27 |
| Diagnostic method | CPET | TTE | CPET | CPET | CPET |
| Observed concordance | 80% | 70% | 90% | 78% | 96% |
| Sensitivity (CI 95%) | 0.86 (0.42–1.0) | 0.67 (0.22–0.96) | 0.89 (0.52–1.0) | 0.78 (0.52–0.94) | 1.00 (0.29–1.0) |
| Specificity (CI 95%) | 0.67 (0.094–0.99) | 0.75 (0.19–0.99) | 1.0 (0.025–1.0) | 0.78 (0.40–0.97) | 0.96 (0.79–1.0) |
| PPV (CI 95%) | 0.86 (0.42–1.0) | 0.8 (0.28–0.99) | 1.0 (0.63–1.0) | 0.88 (0.62–0.98) | 0.75 (0.19–0.99) |
| NPV (CI 95%) | 0.67 (0.094–0.99) | 0.6 (0.15–0.95) | 0.5 (0.013–0.99) | 0.64 (0.31–0.89) | 1.0 (0.85–1.0) |
| McNemar, p value | 0.48 | 1.00 | 1.00 | 0.68 | 1.00 |
P value for McNemar’s test with Yates’ continuity correction (comparisons between diagnostic method and its reference investigation). mPAP: mean pulmonary arterial pressure; ILD: interstitial lung disease; LVD: left ventricular dysfunction; RHC: right heart catheterization; CT: computed tomography; TTE: transthoracic echocardiogram; CPET: cardiopulmonary exercise test; PPV: positive predictive value; NPV: negative predictive value.