Table 2.

Associations of genetic ancestry with RA manifestations.

ManifestationspBonferroni, OR (95% CI)P Value Adjusted for Age, Sex, Smoking, and HLA GRS, OR (95% CI)
ACR criteria
  Morning stiffness< 0.0001, 0.05 (0.02–0.12)< 0.0001, 0.06 (0.02–0.16)
  Rheumatoid factor< 0.0001, 0.22 (0.11–0.44)0.004, 0.33 (0.16–0.70)
  Subcutaneous nodulesn.s.n.s.
  Three or more affected jointsn.s.n.s.
  Symmetrical RAn.s.n.s.
  Anti-CCPn.s.n.s.
  Radiographic changes< 0.0001, 0.05 (0.03–0.10)< 0.0001, 0.06 (0.03–0.11)
Extraarticular manifestations
  Fatiguen.s.n.s.
  Weight loss< 0.0001, 2.85 (1.60–5.05)0.002, 2.55 (1.41–4.64)
  Fevern.s.n.s.
  Muscle weaknessn.s.n.s.
  Muscular atrophyn.s.n.s.
  Osteoporosisn.s.n.s.
  Avascular necrosisn.s.n.s.
  Periungual infarctionn.s.n.s.
  Digital infarctionn.s.n.s.
  Ulcern.s.n.s.
  Palpable purpuran.s.n.s.
  Raynaud syndromen.s.n.s.
  Keratoconjunctivitisn.s.n.s.
  Episcleritisn.s.n.s.
  Scleritisn.s.n.s.
  Scleromalacian.s.n.s.
  Uveitisn.s.n.s.
  Episcleral nodulosisn.s.n.s.
  Cataractn.s.n.s.
  Glaucoman.s.n.s.
  Keratopathyn.s.n.s.
  Retinopathyn.s.n.s.
  Pleural effusionn.s.n.s.
  Pleuritisn.s.n.s.
  Interstitial fibrosisn.s.n.s.
  Lung nodulesn.s.n.s.
  Caplan syndromen.s.n.s.
  Bronchiolitisn.s.n.s.
  Arterial hypertensionn.s.n.s.
  Pericarditisn.s.n.s.
  Myocarditisn.s.n.s.
  Endocardiac diseasen.s.n.s.
  Arrhythmiasn.s.n.s.
  Congenic heart failuren.s.n.s.
  Ischemic vascular diseasen.s.n.s.
  Venous thrombosisn.s.n.s.
  Peripheral neuropathyn.s.n.s.
  Atlantoaxial subluxationn.s.n.s.
  Neuritis (mono- or poly-)n.s.n.s.
  Anemian.s.n.s.
  Thrombocytosisn.s.n.s.
  Thrombocytopenian.s.n.s.
  Eosinophilian.s.n.s.
  Lymphadenopathyn.s.n.s.
  Renal failuren.s.n.s.
  Rheumatoid vasculitisn.s.n.s.
  Infectionsn.s.n.s.
  Neoplasian.s.n.s.
  • RA: rheumatoid arthritis; GRS: genetic risk score; ACR: American College of Rheumatology; anti-CCP: anticyclic citrullinated peptide antibodies; n.s.: not significant.