Analysis of relationship between adverse drug reaction (ADR) and first acute hospitalization, implicated drug-drug interactions, and avoidability of such events in all patients with rheumatoid arthritis (RA).
| ADR-related admissions | Definite | Probable | Possible | Unlikely |
|---|---|---|---|---|
| N (%) | 4 (2.3) | 8 (4.6) | 77 (44.5) | 84 (48.6) |
| RA drug implicated, n (%) | ||||
| Definitely | 2 (50.0) | 4 (50.0) | 40 (51.9) | NA |
| Corticosteroid implicated, n (%) | ||||
| Definitely | 0 (0.0) | 0 (0.0) | 8 (20.0) | |
| Unlikely | 2 (100.0) | 3 (75.0) | 26 (45.0) | |
| DMARD implicated, n (%) | ||||
| Definitely | 2 (100.0) | 3 (75.0) | 27 (67.5) | |
| Unlikely | 0 (0.0) | 1 (25.0) | 9 (22.5) | |
| Biologic implicated, n (%) | ||||
| Definitely | 0 (0.0) | 3 (75.0) | 9 (22.5) | |
| Unlikely | 2 (100.0) | 1 (25.0) | 29 (72.5) | |
| Unlikely | 2 (50.0) | 4 (50.0) | 33 (42.9) | NA |
| Drug-drug interaction implicated, n (%) | ||||
| No | 1 (25.0) | 0 (0.0) | 15 (19.5) | NA |
| Moderate | 1 (25.0) | 5 (62.5) | 57 (74.0) | NA |
| Major | 2 (50.0) | 3 (37.5) | 5 (6.5) | NA |
| Avoidability, n (%) | ||||
| Definitely | 2 (50.0) | 1 (12.5) | 1 (1.3) | NA |
| Possibly | 1 (25.0) | 6 (75.0) | 54 (70.1) | NA |
| Unavoidable | 1 (25.0) | 1 (12.5) | 22 (28.6) | NA |
DMARD: disease-modifying antirheumatic drug; NA: not applicable.