Pathophysiological manifestations visible with HR-pQCT. The state of current and future research goals of SPECTRA within the OMERACT guidelines.
| Variables | Erosions | Joint Space Width | Osteophytes | Bone Microarchitecture | |
|---|---|---|---|---|---|
| Definition | SLR | ✓12 | ✓12 | ✓12 | ✓12 |
| Consensus | ✓15 | ||||
| Criterion validity | Histopathology | ✓16 | |||
| Quantification – manual | Reliability | ✓ 15 | — | — | |
| Responsiveness | o | — | — | ||
| Quantification – semiautomated | Reliability | o | — | — | |
| Responsiveness | o | — | — | ||
| Quantification – automated | Reliability | o | ✓14,17,18 | ||
| Responsiveness | o | o |
HR-pQCT: high-resolution peripheral quantitative computed tomography; SPECTRA: Study grouP for xtrEme-Computed Tomography in Rheumatoid Arthritis; OMERACT: Outcome Measures in Rheumatology; SLR: systematic literature review; ✓: completed tasks; —: unplanned tasks; o: ongoing tasks; empty cells: in future research directions.