Table 1.

Association of knee OA in African Americans with SNP robustly associated with knee OA in prior studies.

SNP	Gene	Chr	Risk/Other Allele	SNP Effect in European Whites			SNP Effect in African Americans
SNP	Gene	Chr	Risk/Other Allele	Frequency of Risk Allele	OR	Ref	Frequency of Risk Allele in AA	Power to Detect OR of Magnitude Seen in Whites^†	OR (95% CI)^‡	P Value from Metaanalysis
rs4730250^*	7q22 (DUS4L)	7	G / A	0.17	1.17	9, 10	0.01	0.10	NA	NA
rs143383	GDF5	20	T / C	0.59–0.68	1.16	11	0.12	0.46	0.92 (0.68–1.24)	0.59
rs11842874	MCF2L	13	A / G	0.91–0.94	1.17	12	0.77	0.56	1.00 (0.80–1.26)	0.98
rs6976	GLT8D1	3	T / C	0.37	1.12	8	0.15	0.34	0.99 (0.75–1.30)	0.95
rs11177	GNL3	3	A / G	0.38	1.12	8	0.17	0.36	0.98 (0.75–1.27)	0.87
rs4836732	ASTN2	9	C / T	0.47	1.20	8	0.67	0.79	1.11 (0.90–1.35)	0.33
rs9350591	FILIP1; SENP6	6	T / C	0.11	1.18	8	0.12	0.54	0.90 (0.67–1.21)	0.48
rs10492367^*	KLHDC5; PTHLH	12	T / G	0.19	1.14	8	0.01	0.09	NA	NA
rs835487	CHST11	12	G / A	0.34	1.13	8	0.64	0.51	0.93 (0.77–1.15)	0.53
rs12107036	TP63	3	G / A	0.52	1.21	8	0.35	0.90	1.12 (0.91–1.38)	0.29
rs8044769	FTO	16	C / T	0.50	1.11	8	0.76	0.32	0.94 (0.75–1.17)	0.56
rs10948172	SUPT3H; CDC5L	6	C / T	0.29	1.14	8	0.30	0.59	0.95 (0.77–1.16)	0.60

↵* SNP with a minor allele frequency < 0.05 were excluded from the metaanalysis.
↵† Power based on 742 cases and 475 controls, p = 0.05, and population prevalence of knee OA = 0.35.
↵‡ OR adjusted for age, sex, and population stratification. OA: osteoarthritis; SNP: single-nucleotide polymorphism; Chr: chromosome; Ref: reference; AA: African Americans; NA: not applicable.